Name | 3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide |
---|---|
Synonyms |
4-[(e)-2-(1h-indol-3-yl)-vinyl]-1-methyl-pyridinium
in1341 Pyridinium, 4-[(E)-2-(1H-indol-3-yl)ethenyl]-1-methyl-, iodide (1:1) Pyridinium, 4-(2-indol-3-ylvinyl)-1-methyl-, iodide 4-[(E)-2-(1H-Indol-3-yl)vinyl]-1-methylpyridinium iodide F16 |
Description | F16 is a small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines. 1, F16 induced cell cycle arrest in sensitive mouse tumor and human cancer cell lines.2, Prolonged incubation with 3 uM F16 resulted in increased cell death of F16-sensitive cells but not of F16-resistant ones.3, F16 caused apoptosis in A6 cells.4, F16 caused a dramatic decrease in the number of cells in S phase and an increase in the percentage of cells in G1 phase.5, F16 is capable of inhibiting oxidative phosphorylation and inducing mitochondrial transmembrane depolarization. |
---|---|
Related Catalog | |
References |
Molecular Formula | C16H15IN2 |
---|---|
Molecular Weight | 362.208 |
Exact Mass | 362.027985 |
PSA | 19.67000 |
LogP | 0.16680 |
Storage condition | 2-8℃ |