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  • DC Chemicals Limited
  • China
  • Product Name: F16
  • Price: $500.0/1g $250.0/250mg $150.0/100mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

36098-33-6

36098-33-6 structure
36098-33-6 structure
  • Name: F16
  • Chemical Name: 3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide
  • CAS Number: 36098-33-6
  • Molecular Formula: C16H15IN2
  • Molecular Weight: 362.208
  • Catalog: Research Areas Cancer
  • Create Date: 2016-03-21 05:49:58
  • Modify Date: 2024-01-06 13:47:20
  • F16 is a small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines. 1, F16 induced cell cycle arrest in sensitive mouse tumor and human cancer cell lines.2, Prolonged incubation with 3 uM F16 resulted in increased cell death of F16-sensitive cells but not of F16-resistant ones.3, F16 caused apoptosis in A6 cells.4, F16 caused a dramatic decrease in the number of cells in S phase and an increase in the percentage of cells in G1 phase.5, F16 is capable of inhibiting oxidative phosphorylation and inducing mitochondrial transmembrane depolarization.

Name 3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide
Synonyms 4-[(e)-2-(1h-indol-3-yl)-vinyl]-1-methyl-pyridinium
in1341
Pyridinium, 4-[(E)-2-(1H-indol-3-yl)ethenyl]-1-methyl-, iodide (1:1)
Pyridinium, 4-(2-indol-3-ylvinyl)-1-methyl-, iodide
4-[(E)-2-(1H-Indol-3-yl)vinyl]-1-methylpyridinium iodide
F16
Description F16 is a small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines. 1, F16 induced cell cycle arrest in sensitive mouse tumor and human cancer cell lines.2, Prolonged incubation with 3 uM F16 resulted in increased cell death of F16-sensitive cells but not of F16-resistant ones.3, F16 caused apoptosis in A6 cells.4, F16 caused a dramatic decrease in the number of cells in S phase and an increase in the percentage of cells in G1 phase.5, F16 is capable of inhibiting oxidative phosphorylation and inducing mitochondrial transmembrane depolarization.
Related Catalog
References

[1]. Fantin VR et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul;2(1):29-42.

[2]. Fantin VR et al. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 1;64(1):329-36.

Molecular Formula C16H15IN2
Molecular Weight 362.208
Exact Mass 362.027985
PSA 19.67000
LogP 0.16680
Storage condition 2-8℃