51234-28-7

51234-28-7 structure

Name: Benoxaprofen
Chemical Name: benoxaprofen
CAS Number: 51234-28-7
Molecular Formula: C₁₆H₁₂ClNO₃
Molecular Weight: 301.724
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-05-06 08:00:00
Modify Date: 2026-07-16 12:58:28
Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen is a relatively weak inhibitor of cyclooxygenase in in vitro systems, inhibits lipoxygenase in other systems, and inhibits monocyte migration in some animal models of inflammation[1][2].

Name	benoxaprofen
Synonyms	Benoxaprofen, 10 mM in DMSO Inflamid 2-(4-Chlorophenyl)-α-methyl-5-benzoxazoleacetic acid 2-(4-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid LY-90459 dl-Benoxaprofen 5-Benzoxazoleacetic acid, 2-(4-chlorophenyl)-α-methyl Uniprofen inflammation,CL-3794,monocyte miation,inhibit,COX,Cyclooxygenase,CL 3794,CL3794,Inhibitor,lipoxygenase,Benoxaprofen,antipyretic compound 2-(2-(4-Chlorophenyl)-1,3-benzoxazol-5-yl)propanoic acid Coxigon Aids-128826 2-[2-(4-Chlorophenyl)-5-benzoxazolyl]propanoic Acid 5-Benzoxazoleacetic acid, 2-(4-chlorophenyl)-.alpha.-methyl 2-[2-(4-Chlorophenyl)benzoxazol-5-yl]-propanoic Acid 2-(p-Chlorophenyl)-.alpha.-methyl-5-benzoxazoleacetic acid CL-3794 (2R)-2-[2-(4-Chlorophenyl)-1,3-benzoxazol-5-yl]propanoic acid Benoxaphen. Compound Lilly-90459 Oraflex Aids128826 2-(2-(4-chlorophenyl)benzo[d]oxazol-5-yl)propanoic acid 4H-1-Benzopyran-4-one,7-hydroxy-3-(trifluoromethyl) Opren Compound-90459

Description	Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen is a relatively weak inhibitor of cyclooxygenase in in vitro systems, inhibits lipoxygenase in other systems, and inhibits monocyte migration in some animal models of inflammation[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
References	[1]. Cashin CH, et al. The pharmacology of benoxaprofen (2-[4-chlorophenyl]-alpha-methyl-5-benzoxazole acetic acid), LRCL 3794, a new compound with antiinflammatory activity apparently unrelated to inhibition of prostaglandin synthesis. J Pharm Pharmacol. 1977;29(6):330-336.

Density	1.4±0.1 g/cm3
Boiling Point	446.2±30.0 °C at 760 mmHg
Melting Point	189.5 °C
Molecular Formula	C₁₆H₁₂ClNO₃
Molecular Weight	301.724
Flash Point	223.6±24.6 °C
Exact Mass	301.050568
PSA	63.33000
LogP	4.41
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.639
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DM4447000

CHEMICAL NAME :: 5-Benzoxazoleacetic acid, 2-(4-chlorophenyl)-alpha-methyl-

CAS REGISTRY NUMBER :: 51234-28-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C16-H12-Cl-N-O3

MOLECULAR WEIGHT :: 301.74

WISWESSER LINE NOTATION :: T56 BN DOJ CR DG& HY1&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 168 mg/kg/2W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume decreased Blood - eosinophilia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 780 mg/kg/13W-I

TOXIC EFFECTS :: Endocrine - gynecomastia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 552 mg/kg/46D-C

TOXIC EFFECTS :: Liver - jaundice, other or unclassified

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 780 mg/kg/65D-C

TOXIC EFFECTS :: Liver - jaundice, other or unclassified

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 118 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Blood - aplastic anemia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 129 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 121 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 398 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 482 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1050 mg/kg/35D-I

TOXIC EFFECTS :: Endocrine - changes in thymus weight Blood - normocytic anemia Blood - other changes

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Human Leukocyte

DOSE/DURATION :: 15 mg/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,3094,1988

Precursor 9
87498-09-7 21850-61-3 51234-22-1 28694-90-8
51234-41-4 51234-23-2 51234-36-7 122-01-0
51234-43-6
DownStream 2
51234-41-4 51234-57-2

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