Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: efloxate
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Purity: 98.0%
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119-41-5

119-41-5 structure

119-41-5 structure

Name: Efloxate
Chemical Name: ethyl 2-(4-oxo-2-phenylchromen-7-yl)oxyacetate
CAS Number: 119-41-5
Molecular Formula: C₁₉H₁₆O₅
Molecular Weight: 324.32700
Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
Create Date: 2018-06-25 12:05:33
Modify Date: 2024-01-01 19:57:19
Efloxate is a vasodilator, used to treat chronic coronary insufficiency and Angina pectoris,

Name	ethyl 2-(4-oxo-2-phenylchromen-7-yl)oxyacetate
Synonyms	Corosanin Efloxatum Recordil Oxyflavil [(4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy]-acetic acid,ethyl ester (4-Oxo-2-phenyl-4H-chromen-7-yloxy)-essigsaeure-aethylester Coril EINECS 204-321-9 Efloxate (4-oxo-2-phenyl-4H-chromen-7-yloxy)-acetic acid ethyl ester Angorlisin Oxiflavil Flacethyle 7-ethoxycarbonylmethoxyflavone Domucor

Description	Efloxate is a vasodilator, used to treat chronic coronary insufficiency and Angina pectoris,
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease

Density	1.265g/cm3
Boiling Point	486.5ºC at 760 mmHg
Melting Point	123-124°
Molecular Formula	C₁₉H₁₆O₅
Molecular Weight	324.32700
Flash Point	269.1ºC
Exact Mass	324.10000
PSA	65.74000
LogP	3.40190
Vapour Pressure	1.28E-09mmHg at 25°C
Index of Refraction	1.59
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AJ1460000

CHEMICAL NAME :: Acetic acid, ((4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy)-, ethyl ester

CAS REGISTRY NUMBER :: 119-41-5

BEILSTEIN REFERENCE NO. :: 0313027

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H16-O5

MOLECULAR WEIGHT :: 324.35

WISWESSER LINE NOTATION :: T66 BO EVJ CR& IO1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,125,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,125,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 13,561,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,125,1982

HS Code	2918990090

6665-86-7 structure

6665-86-7

105-36-2 structure

105-36-2

~%

119-41-5 structure

119-41-5

Literature: Tobe, Masanori; Isobe, Yoshiaki; Goto, Yuso; Obara, Fumihiro; Tsuchiya, Masami; Matsui, Junko; Hirota, Kosaku; Hayashi, Hideya Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 2037 - 2047

6665-86-7 structure

6665-86-7

105-39-5 structure

105-39-5

~%

119-41-5 structure

119-41-5

Literature: Zwaagstra; Timmerman; Abdoelgafoer; Zhang European Journal of Medicinal Chemistry, 1996 , vol. 31, # 11 p. 861 - 874

89-84-9 structure

89-84-9

~%

119-41-5 structure

119-41-5

Literature: Da Re; Colleoni Annali di Chimica (Rome, Italy), 1959 , vol. 49, p. 1632,1636

Precursor 4
6665-86-7 105-36-2 105-39-5 89-84-9
DownStream 0

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%