Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: Nafimidone
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70891-37-1

70891-37-1 structure

70891-37-1 structure

Name: Nafimidone
Chemical Name: 2-imidazol-1-yl-1-naphthalen-2-ylethanone,hydrochloride
CAS Number: 70891-37-1
Molecular Formula: C₁₅H₁₃ClN₂O
Molecular Weight: 272.73000
Create Date: 2016-04-05 10:09:50
Modify Date: 2024-01-11 18:04:36

Name	2-imidazol-1-yl-1-naphthalen-2-ylethanone,hydrochloride
Synonyms	2-imidazol-1-yl-1-naphthalen-2-yl-ethanone hydrochloride 2-(1H-Imidazol-1-yl)-1-(2-naphthalenyl)ethanone monohydrochloride Nafimidone hydrochloride (USAN) Ethanone,2-(1H-imidazol-1-yl)-1-(2-naphthalenyl)-,monohydrochloride 2-(1-Imidazolylacetyl)naphthalene hydrochloride 2'-ACETONAPHTHONE,2-(1-IMIDAZOLYL)-,HYDROCHLORIDE Nafimidone HCl 1-(2-Naphthoylmethyl)imidazole hydrochloride 2-(1H-imidazol-1-yl)-1-(naphthalen-2-yl)ethanone hydrochloride Nafimidone hydrochloride

Molecular Formula	C₁₅H₁₃ClN₂O
Molecular Weight	272.73000
Exact Mass	272.07200
PSA	34.89000
LogP	3.72120

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM5780880

CHEMICAL NAME :: Ethanone, 2-(1H-imidazol-1-yl)-1-(2-naphthalenyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 70891-37-1

LAST UPDATED :: 199203

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H12-N2-O.Cl-H

MOLECULAR WEIGHT :: 272.75

WISWESSER LINE NOTATION :: L66J BV1- AT5N CNJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 504 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,1577,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 120,185,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 120,185,1981

HS Code	2934999090

288-32-4 structure

288-32-4

613-54-7 structure

613-54-7

~38%

70891-37-1 structure

70891-37-1

Literature: Roman, Gheorghe; Vlahakis, Jason Z.; Vukomanovic, Dragic; Nakatsu, Kanji; Szarek, Walter A. ChemMedChem, 2010 , vol. 5, # 9 p. 1541 - 1555

Precursor 2
288-32-4 613-54-7
DownStream 3
70891-42-8 70891-65-5 71009-17-1

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%