103926-64-3

103926-64-3 structure

Name: Sepimostat
Chemical Name: (6-carbamimidoylnaphthalen-2-yl) 4-(4,5-dihydro-1H-imidazol-2-ylamino)benzoate
CAS Number: 103926-64-3
Molecular Formula: C₂₁H₁₉N₅O₂
Molecular Weight: 373.40800
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-08-21 15:27:33
Modify Date: 2024-01-10 11:44:32
Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7 µM[1].

Name	(6-carbamimidoylnaphthalen-2-yl) 4-(4,5-dihydro-1H-imidazol-2-ylamino)benzoate
Synonyms	UNII-5ZFR16F4QQ Sepimostat [INN] Sepimostat

Description	Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7 µM[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vivo	Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect[1]. Animal Model: Male Sprague Dawley rats weighing 150-300 g[1]. Dosage: Intravitreal injection. Administration: 1 to 100 nmol/eye. Result: Exhibited neuroprotective effects significantly.
References	[1]. Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.