205754-33-2
205754-33-2 structure
- Name: 8-Hydroxy-efavirenz
- Chemical Name: rac 8-hydroxy efavirenz
- CAS Number: 205754-33-2
- Molecular Formula: C14H9ClF3NO3
- Molecular Weight: 331.674
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2016-10-28 18:23:41
- Modify Date: 2024-01-17 19:58:25
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8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of Efavirenz (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer[1].
| Name | rac 8-hydroxy efavirenz |
|---|---|
| Synonyms |
8-HYDROXY EFAVIRENZ
2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)- 6-Chloro-4-(cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one 6-Chloro-4-(cyclopropyl-d4-ethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one (S)-6-chloro-4-(cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one |
| Description | 8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of Efavirenz (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 8-Hydroxyefavirenz (8-OH-EFV; 1-10 μM; 3-24 h; 原代人肝细胞) 以时间和浓度依赖的方式增加细胞死亡，并从 6 小时开始诱导 caspase-3 活性[1]。 8-Hydroxyefavirenz (1-10 μM; 6-24 h) 刺激原代人肝细胞中线粒体 ROS 的产生[1]。 8-Hydroxyefavirenz (10 μM; 3-24 h) 激活 JNK 并使磷酸化的 JNK 占总 JNK 的比例增加 4.2 倍。8-Hydroxyefavirenz 增加 BimEL mRNA 和蛋白表达[1]。 Cell Viability Assay[1] Cell Line: Primary human hepatocytes Concentration: 1 and 10 μM Incubation Time: 3, 6, 12 and 24 hours Result: Increased cell death in a time- and concentration-dependent manner and increased cell death by 3.4-fold at 6 h. Western Blot Analysis[1] Cell Line: Primary human hepatocytes Concentration: 1 and 10 μM Incubation Time: 3, 6, 12 and 24 hours Result: Increased the expression of cleaved caspase-3 in a time- and concentration-dependent manner. Western Blot Analysis[1] Cell Line: Primary human hepatocytes Concentration: 1 and 10 μM Incubation Time: 3, 6, 12 and 24 hours Result: Increased the phosphorylation of JNK and increased the mRNA and protein expression of BimEL. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 373.6±42.0 °C at 760 mmHg |
| Melting Point | 144-154ºC |
| Molecular Formula | C14H9ClF3NO3 |
| Molecular Weight | 331.674 |
| Flash Point | 179.7±27.9 °C |
| Exact Mass | 331.022308 |
| PSA | 58.56000 |
| LogP | 4.80 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.608 |
| Precursor 6 | |
|---|---|
| DownStream 0 | |