85490-53-5

85490-53-5 structure

Name: Motilin (canine)
Chemical Name: Motilin canine
CAS Number: 85490-53-5
Molecular Formula: C₁₂₀H₁₉₄N₃₆O₃₄
Molecular Weight: 2685.05000
Catalog: Peptides
Create Date: 2019-02-19 16:58:05
Modify Date: 2024-01-01 19:51:05
Motilin, canine is a 22-amino acid peptide. Motilin is a potent agonist for gastrointestinal smooth muscle contraction.

Name	Motilin canine
Synonyms	Motilin Motilin, canine

Description	Motilin, canine is a 22-amino acid peptide. Motilin is a potent agonist for gastrointestinal smooth muscle contraction.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Peptides
In Vivo	Motilin is a potent agonist for gastrointestinal smooth muscle contraction and has been proposed to regulate the onset of phase III of the migrating motor complex (MMC) in dogs and humans. In the dog, but not in the human, Motilin also contracts the gallbladder and sphincter of Oddi and induces pancreatic secretion. Motilin activates L-type Ca2+ channel (IcaL) in canine jejunal circular smooth muscle cells through a G protein-coupled mechanism. At 1 μM, Motilin increases IcaL in canine jejunal circular smooth muscle cells by 43±20[1].
References	[1]. Farrugia G, et al. Motilin and OHM-11526 activate a calcium current in human and canine jejunal circular smooth muscle. Am J Physiol. 1997 Aug;273(2 Pt 1):G404-12.