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117399-93-6

117399-93-6 structure

117399-93-6 structure

Name: Endothelin-3 (human, mouse, rabbit, rat) acetate salt
Chemical Name: Endothelin 3 human, rat
CAS Number: 117399-93-6
Molecular Formula: C₁₂₁H₁₆₈N₂₆O₃₃S₄
Molecular Weight: 2643.04000
Catalog: Biochemical Peptide
Create Date: 2018-07-11 21:43:36
Modify Date: 2026-07-10 10:28:43
Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

Name	Endothelin 3 human, rat
Synonyms	Endothelin-3, human ENDOTHELIN 3 HUMAN, RAT ET-3, HUMAN ENDOTHELIN-3, HUMAN Endothelin 3 (Rat,Human) ENDOTHELIN 3, HUMAN, RAT Anti-EDN3 antibody produced in rabbit Endothelin-3 (huMan, Mouse, rabbit, rat) ET-3 (huMan, Mouse, rabbit, rat) CTCFTYKDKECVYYCHLDIIW (DISULFIDE BRIDGE: AND ) ET-3 (HUMAN, MOUSE, RABBIT, RAT) CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR- TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP(DISULFIDE BRIDGE:CYS1-CYS15, CYS3-CYS11) Human endothelin-3 33,34,49,50-Tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecaazabicyclo[23.22.4]henpentacontane, cyclic ptide deriv EDN3 ET-3, HUMAN AND RAT ANTI-EDN3 (C-TERM) antibody produced in rabbit Human endothelin-3/Rat endothelin-3 HSCR4 Endothelin 3 ET-3 (HUMAN, RAT) Endothelin 3 huMan, ratEndothelin L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-α-asptyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-α-asptyl-L-isoleucyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide) CTCFTYKDKECVYYCHLDIIW ET-3 19: PN: WO2007112069 SEQID: 10 claimed protein et-3 CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP: CTCFTYKDKECVYYCHLDIIW DISULFIDE BRIDGES CYS1-CYS15, CYS3-CYS11 human,rat H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH //BP ENDOTHELIN-3 (HUMAN, RAT, PIG) WS4B ENDOTHELIN 3, HUMAN AND RAT ENDOTHELIN-3 (HUMAN) (PORCINE, RAT, RABBIT) CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP Endothelin 3, human, rat, mouse, rabbit ENDOTHELIN-3 (HUMAN, MOUSE, RABBIT, RAT) Endothelin 3 (huMan)(9CI) H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH (DISULFIDE BRIDGE: AND ) Endothelin 3, human, rat, (HPLC), powder Rat endothelin-3 MFCD00076378 Endothelin 3 human,rat Endothelin 3 human, rat (TFA) CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP HUMAN, RAT, PORCINE, RABBIT ENDOTHELIN-III, HUMAN, RAT Endothelin 3 (mouse intestine) ENDOTHELIN-3 (HUMAN, RAT, PORCINE, RABBIT) PPET3 H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH ET-3 (HUMAN, RAT, PIG) Endothelin-3, human, mouse, rabbit, rat (3S)-3-[[(2S)-2-[[(2S)-2-[[(1R,4S,7S,10S,13S,16S,19S,22S,25R,28S,31R,36R,39S,42S,45S)-31-amino-7,13-bis(4-aminobutyl)-22-benzyl-4-(2 -cboxyethyl)-10-(cboxymethyl)-19,28-bis[(1R)-1-hydroxyethyl]-16,39,42-tris[(4-hydroxyphenyl)methyl]-3,6,9,12,15,18,21 C121H168N26O33S4 ENDOTHELIN-3 Endothelin 3, Human and Rat - - Calbiochem Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11)

Description	Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.
Related Catalog	Signaling Pathways >> Others >> Others Peptides Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease
Target	ET-RA, ET-RB[1]
In Vitro	The endothelins (ETs) are a family of 21-amino-acid vasoconstrictor peptides comprising three distinct isoforms: ET-1, ET2 and Endothelin-3. Endothelin-3 is detected in plasma, heart, brain and vascular smooth muscle cells (VSMCs). The surface enzymes of VSMCs break down big Endothelin-3 to the corresponding mature peptide, Endothelin-3. Endothelin-3 down-regulate endothelin ETA receptor expression in coronary artery VSMCs without affecting receptor density or functional ETA receptor responses. By contrast, high concentrations of Endothelin-3 (100 nM) increase the expression of ETB receptors but abolish the vasoconstrictor response of the receptors, possibly due to the desensitizing effect of Endothelin-3[1]. Endothelin-3 stimulates ENCC adhesion to various ECM components. Endothelin-3 induces rapid changes in ENCC shape and protrusion dynamics favouring sustained growth and stabilization of lamellipodia, a process coincident with the increase in the number of focal adhesions and activated β1-integrins[2].
In Vivo	Endothelin-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and NO production. Endothelin-3, which acts mainly on ETB, at low concentrations specifically inhibited platelet-activating factor (PAF)-induced paw oedema, whereas neither ET-1 nor Endothelin-2, both of which act on ETA and ETB, showed inhibitory activity. The inhibition by ET-1 and Endothelin-3 (each 0.5 pmol/paw) in the presence of BQ-123 (66.4 ± 6.7 % and 65.4 ± 22.6 %, respectively), is comparable to that by Endothelin-3 (0.5 pmol/paw) alone (65.4 ± 10.9 %), whereas neither ET-1 nor Endothelin-3 in the presence of BQ-788 showed inhibitory activity[3].
References	[1]. Skovsted GF, et al. Endothelin-1 and Endothelin-3 Regulate Endothelin Receptor Expression in Rat Coronary Arteries. Basic Clin Pharmacol Toxicol. 2015 Nov;117(5):297-305. [2]. Gazquez E, et al. Endothelin-3 stimulates cell adhesion and cooperates with β1-integrins during enteric nervous system ontogenesis. Sci Rep. 2016 Dec 1;6:37877. doi: 10.1038/srep37877. [3]. Sato A, et al. Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor. Inflamm Res. 2013 Apr;62(4):417-24.

Molecular Formula	C₁₂₁H₁₆₈N₂₆O₃₃S₄
Molecular Weight	2643.04000
Exact Mass	2641.11000
PSA	1056.08000
LogP	6.33930
Appearance	powder \| white
Storage condition	−20°C

Safety Phrases	S22
RIDADR	NONH for all modes of transport
WGK Germany	3

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