- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Endothelin3human,rat
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- GL Biochem (Shanghai) Ltd.
- China
- Product Name: Endothelin-3, human
- Price: $Inquiry/1kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Jackie Yang
- Nanjing Peptide Biotech Ltd
- China
- Product Name: H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Stocking Period: 7 Day
- Contact: jom
- Taiwan Oyi peptide Co. Ltd
- China
- Product Name: Endothelin-3 (human, mouse, rabbit, rat) acetate salt
- Price: $Inquiry/1mg $Inquiry/100kg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Vinnie
117399-93-6
117399-93-6 structure
- Name: Endothelin-3 (human, mouse, rabbit, rat) acetate salt
- Chemical Name: Endothelin 3 human, rat
- CAS Number: 117399-93-6
- Molecular Formula: C121H168N26O33S4
- Molecular Weight: 2643.04000
- Catalog: Biochemical Peptide
- Create Date: 2018-07-11 21:43:36
- Modify Date: 2024-01-05 19:54:49
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Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.
| Name | Endothelin 3 human, rat |
|---|---|
| Synonyms |
ET-3
MFCD00076378 Endothelin 3 human,rat Endothelin-3, human Endothelin-3, human, mouse, rabbit, rat |
| Description | Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB. |
|---|---|
| Related Catalog | |
| Target |
ET-RA, ET-RB[1] |
| In Vitro | The endothelins (ETs) are a family of 21-amino-acid vasoconstrictor peptides comprising three distinct isoforms: ET-1, ET2 and Endothelin-3. Endothelin-3 is detected in plasma, heart, brain and vascular smooth muscle cells (VSMCs). The surface enzymes of VSMCs break down big Endothelin-3 to the corresponding mature peptide, Endothelin-3. Endothelin-3 down-regulate endothelin ETA receptor expression in coronary artery VSMCs without affecting receptor density or functional ETA receptor responses. By contrast, high concentrations of Endothelin-3 (100 nM) increase the expression of ETB receptors but abolish the vasoconstrictor response of the receptors, possibly due to the desensitizing effect of Endothelin-3[1]. Endothelin-3 stimulates ENCC adhesion to various ECM components. Endothelin-3 induces rapid changes in ENCC shape and protrusion dynamics favouring sustained growth and stabilization of lamellipodia, a process coincident with the increase in the number of focal adhesions and activated β1-integrins[2]. |
| In Vivo | Endothelin-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and NO production. Endothelin-3, which acts mainly on ETB, at low concentrations specifically inhibited platelet-activating factor (PAF)-induced paw oedema, whereas neither ET-1 nor Endothelin-2, both of which act on ETA and ETB, showed inhibitory activity. The inhibition by ET-1 and Endothelin-3 (each 0.5 pmol/paw) in the presence of BQ-123 (66.4 ± 6.7 % and 65.4 ± 22.6 %, respectively), is comparable to that by Endothelin-3 (0.5 pmol/paw) alone (65.4 ± 10.9 %), whereas neither ET-1 nor Endothelin-3 in the presence of BQ-788 showed inhibitory activity[3]. |
| References |
| Molecular Formula | C121H168N26O33S4 |
|---|---|
| Molecular Weight | 2643.04000 |
| Exact Mass | 2641.11000 |
| PSA | 1056.08000 |
| LogP | 6.33930 |
| Appearance | powder | white |
| Storage condition | −20°C |
| Safety Phrases | S22 |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |