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1867-73-8

1867-73-8 structure
1867-73-8 structure
  • Name: N6-Methyladenosine
  • Chemical Name: N6-methyladenosine
  • CAS Number: 1867-73-8
  • Molecular Formula: C11H15N5O4
  • Molecular Weight: 281.26800
  • Catalog: Research Areas Others
  • Create Date: 2018-06-11 09:37:23
  • Modify Date: 2024-01-03 07:30:54
  • N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes.
Name N6-methyladenosine
Synonyms N-Methyladenosine
6-methylaminopurine riboside
N(6)-methyladenosine
Adenosine,N-methyl
6-N-Methyladenoside
n6-methyladenosine
6-Methylaminopurine D-riboside
6-METHYLAMINOPURINE 9-RIBOFURANOSIDE
6-Methylaminopurine ribonucleoside
6-Methylaminopurinosine
Description N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes.
Related Catalog
In Vitro N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion[1]. N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits[2].
References

[1]. Wang X, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20.

[2]. Li Y, et al. Genome-wide detection of high abundance N6-methyladenosine sites by microarray. RNA. 2015 Aug;21(8):1511-8.
Density 1.85g/cm3
Boiling Point 649.1ºC at 760mmHg
Molecular Formula C11H15N5O4
Molecular Weight 281.26800
Flash Point 346.3ºC
Exact Mass 281.11200
PSA 125.55000
Vapour Pressure 9.86E-18mmHg at 25°C
Index of Refraction 1.814
Storage condition 2-8°C
Hazard Codes Xi
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 1867-73-8 | Chemsrc address: https://m.chemsrc.com/en/baike/445632.html

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