149-17-7

149-17-7 structure

149-17-7 structure

Name: Ftivazide
Chemical Name: N'-[(E)-(3-methoxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]pyridine-4-carbohydrazide
CAS Number: 149-17-7
Molecular Formula: C₁₄H₁₃N₃O₃
Molecular Weight: 271.27
Catalog: API Synthetic anti-infective drugs Anti-tuberculosis leprosy
Create Date: 2018-09-16 20:04:27
Modify Date: 2024-01-03 19:33:00
Ftivazide has anti-tuberculosis activity[1].

Name	N'-[(E)-(3-methoxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]pyridine-4-carbohydrazide
Synonyms	4-Hydroxy-5-methoxy-benzaldehyd-isonicotinoylhydrazon Isonicotinic acid vanillylidenehydrazide Phthivazid Phtivazide Isonicotinsaeure-vanillylidenhydrazid Ftivazide Vancide Vanizide 3-Methoxy-4-hydroxy-benzaldehyd-isonicotinoylhydrazon Phthivazidum Vanillaberon

Description	Ftivazide has anti-tuberculosis activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Dmitriy Khrustalev, et al. Synthesis of anti-tuberculosis drugs in a microwave flow reactor. Materials Today: Proceedings, 2023, 81: 1186-1191.

Density	1.3g/cm3
Boiling Point	441.6ºC at 760 mmHg
Melting Point	219-220°C (lit.)
Molecular Formula	C₁₄H₁₃N₃O₃
Molecular Weight	271.27
Flash Point	220.9ºC
Exact Mass	271.09600
PSA	83.81000
LogP	1.95060
Vapour Pressure	5.36E-08mmHg at 25°C
Index of Refraction	1.619

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NS2298000

CHEMICAL NAME :: Isonicotinic acid, vanillylidenehydrazide

CAS REGISTRY NUMBER :: 149-17-7

BEILSTEIN REFERENCE NO. :: 0234808

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H13-N3-O3

MOLECULAR WEIGHT :: 271.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24960 mg/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 18(6),50,1972

HS Code	2933399090

54-85-3 structure

54-85-3

121-33-5 structure

121-33-5

~75%

149-17-7 structure

149-17-7

Literature: Shah; Mehta; Parikh Journal of the Indian Chemical Society, 1985 , vol. 62, # 3 p. 255 - 257

1570-45-2 structure

1570-45-2

~%

149-17-7 structure

149-17-7

Literature: Meyer,H.; Mally Monatshefte fuer Chemie, 1912 , vol. 33, p. 403

Precursor 3
54-85-3 121-33-5 1570-45-2
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%