4758-99-0

4758-99-0 structure

Name: Guanfu base H
Chemical Name: atisine, hydrochloride
CAS Number: 4758-99-0
Molecular Formula: C₂₂H₃₄ClNO₂
Molecular Weight: 379.96400
Catalog: Research Areas Infection
Create Date: 2017-12-19 01:52:35
Modify Date: 2024-01-02 18:13:50
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively[1][2].

Name	atisine, hydrochloride

Description	Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively[1][2].
Related Catalog	Research Areas >> Infection
Target	Plasmodium falciparum[2]
References	[1]. WU Qiong, et al. Simultaneous Determination of Guanfu Base A,Guanfu Base I and Guanfu Base H in Radix Aconitum coreanum(Lévl) Rapaics by RP-HPLC. Progress in Pharmaceutical Sciences. 2011, 35(5), 230-233. [2]. Wangchuk P, et al. Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum. J Ethnopharmacol. 2010 Aug 9;130(3):559-62.