Guanfu base H

Modify Date: 2025-08-26 11:51:47

Guanfu base H Structure
Guanfu base H structure
 Common Name Guanfu base H
CAS Number 4758-99-0 Molecular Weight 379.96400
Density N/A Boiling Point N/A
Molecular Formula C22H34ClNO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Guanfu base H


Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively[1][2].

 Names

Name atisine, hydrochloride

 Guanfu base H Biological Activity

Description Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively[1][2].
Related Catalog
Target

Plasmodium falciparum[2]

References

[1]. WU Qiong, et al. Simultaneous Determination of Guanfu Base A,Guanfu Base I and Guanfu Base H in Radix Aconitum coreanum(Lévl) Rapaics by RP-HPLC. Progress in Pharmaceutical Sciences. 2011, 35(5), 230-233.

[2]. Wangchuk P, et al. Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum. J Ethnopharmacol. 2010 Aug 9;130(3):559-62.

 Chemical & Physical Properties

Molecular Formula C22H34ClNO2
Molecular Weight 379.96400
Exact Mass 379.22800
PSA 43.47000
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