3637-11-4

3637-11-4 structure

Name: 4-Piperidone, 1-hydroxy-2,2,6,6-tetramethyl-
Chemical Name: 1-hydroxy-2,2,6,6-tetramethylpiperidin-4-one
CAS Number: 3637-11-4
Molecular Formula: C₉H₁₇NO₂
Molecular Weight: 171.23700
Catalog: Research Areas Neurological Disease
Create Date: 2016-12-14 19:11:46
Modify Date: 2024-01-03 19:51:05
Tempone-H may be used as a spin trap in chemical and biological systems to quantify peroxynitrite and superoxide radical formation. Ferric and cupric ions are effective oxidants of Tempone-H[1][2].

Name	1-hydroxy-2,2,6,6-tetramethylpiperidin-4-one
Synonyms	1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-one 1-Hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine 4-oxo-TEMPO-H 4-Piperidinone,1-hydroxy-2,2,6,6-tetramethyl 1-Hydroxy-2,2,6,6-tetramethyl-piperidin-4-on 2,2,6,6-tetramethyl-4-oxo-1-piperidinyloxy Tempone-H N-hydroxy-4-oxo-2,2,6,6-tetramethylpiperidine 1-Hydroxy-2,2,6,6-tetramethyl-4-piperidinone

Description	Tempone-H may be used as a spin trap in chemical and biological systems to quantify peroxynitrite and superoxide radical formation. Ferric and cupric ions are effective oxidants of Tempone-H[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Using TEMPONE-H the obtained sensitivity in the detection of peroxynitrite or superoxide radicals is about 10-fold higher than using the spin traps DMPO or TMIO[1].
References	[1]. Dikalov S, et al. Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine. Biochem Biophys Res Commun. 1997 Jan 3;230(1):54-7. [2]. Dikalov SI, et al. Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides. J Biol Chem. 1999 Apr 2;274(14):9392-9.

HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%