Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: artonin E
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Purity: 98.0%
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129683-93-8

129683-93-8 structure

Name: artonin E
Chemical Name: 5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)-2-(2,4,5-trihydroxyphenyl)pyrano[2,3-h]chromen-4-one
CAS Number: 129683-93-8
Molecular Formula: C₂₅H₂₄O₇
Molecular Weight: 436.45400
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-03-02 10:55:50
Modify Date: 2024-01-02 18:34:43
Artonin E (5'-Hydroxymorusin) is a known prenylated flavonoid that induces apoptosis and arrests the cell cycle in S phase. Artonin E can induce anti-proliferative effects through mitochondrial pathway dysregulation and can be used in cancer research[1].

Name	5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)-2-(2,4,5-trihydroxyphenyl)pyrano[2,3-h]chromen-4-one
Synonyms	Artonin E 5'-Hydroxymorusin

Description	Artonin E (5'-Hydroxymorusin) is a known prenylated flavonoid that induces apoptosis and arrests the cell cycle in S phase. Artonin E can induce anti-proliferative effects through mitochondrial pathway dysregulation and can be used in cancer research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Artonin E (0-100 μg/mL, 24-72 h) 作用于 SKOV-3 细胞、T1074 细胞、人牙周膜成纤维细胞和 CHO 细胞的 IC50 值分别是 12.83、44.8、67 和 57.6 μg/mL。并且可以以时间依赖性方式降低 SKOV-3 细胞的细胞活力[1]。 Artonin E (0-20 μg/mL, 24 h) 可以以剂量依赖性方式抑制 SKOV-3 细胞集落形成，在 5 μg/mL 下，几乎一半的菌落减少，在用 15 和 20 μg/mL时，没有形成集落[1]。 Artonin E (8 μg/mL, 24-72 h) 可以诱导处于 S 期的 SKOV-3 细胞耗竭，72 小时时，S 期停滞的细胞积累显着增加，同时 G0/G1 期细胞比例下降[1]。 Cell Cycle Analysis[1] Cell Line: SKOV-3 cell lines Concentration: 8 μg/mL Incubation Time: 24, 48, 72 h Result: Induced ROS formation. Induced disruption of mitochondrial membrane potential and release of cytochrome c. Significantly upregulated the protein expression levels of caspase-9 and -3,up-regulated Bax and inhibited the expression of Bcl-2, HSP70 and survivin.
References	[1]. Mashitoh Abd Rahman, et al. Artonin E Induces Apoptosis via Mitochondrial Dysregulation in SKOV-3 Ovarian Cancer Cells. PLoS One. 2016 Mar 28;11(3):e0151466.

Density	1.359g/cm3
Boiling Point	698.7ºC at 760 mmHg
Molecular Formula	C₂₅H₂₄O₇
Molecular Weight	436.45400
Flash Point	241.5ºC
Exact Mass	436.15200
PSA	120.36000
LogP	4.97530
Vapour Pressure	3.59E-20mmHg at 25°C
Index of Refraction	1.653

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