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  • DC Chemicals Limited
  • China
  • Product Name: Hepln-13
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

64369-13-7

64369-13-7 structure
64369-13-7 structure
  • Name: HepIn-13
  • Chemical Name: 2-(4-Brom-phenyl)-2,3-dihydro-1H-perimidin
  • CAS Number: 64369-13-7
  • Molecular Formula: C17H13BrN2
  • Molecular Weight: 325.20300
  • Catalog: Research Areas Cancer
  • Create Date: 2016-10-02 21:49:08
  • Modify Date: 2024-01-10 09:36:07
  • Hepln-13 is a potent and orally active Hepsin inhibitor with an IC50 of 0.33 µM. Hepln-13 can be used for the research of metastatic prostate cancer[1].

Name 2-(4-Brom-phenyl)-2,3-dihydro-1H-perimidin
Synonyms 1h-naphth[1,2-e][1,3]oxazine,2-(4-bromophenyl)-2,3-dihydro
2-(4-bromo-phenyl)-2,3-dihydro-1H-perimidine
2-<4-Brom-phenyl>-2.3-dihydro-1H-naphth<1.2-e>-1.3-oxazin
2-(4-bromo-phenyl)-2,3-dihydro-1H-naphth[1,2-e][1,3]oxazine
2-(4-bromophenyl)-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine
Description Hepln-13 is a potent and orally active Hepsin inhibitor with an IC50 of 0.33 µM. Hepln-13 can be used for the research of metastatic prostate cancer[1].
Related Catalog
Target

IC50: 0.33 μM (Hepsin)

In Vitro Hepln-13 (10 µM; 2 hours; 293 cells) inhibits cleavage[1]. Western Blot Analysis[1] Cell Line: 293 cells Concentration: 10 µM Incubation Time: 2 hours Result: Inhibited cleavage.
In Vivo HepIn-13 displays dose dependent inhibition of Hepsin overexpression-relevant prostate cancer phenotypes and blocks prostate cancer metastasis[1].
References

[1]. Tang X, et al. Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis. Oncotarget. 2014;5(5):1352-1362.

Density 1.444g/cm3
Boiling Point 533.3ºC at 760 mmHg
Molecular Formula C17H13BrN2
Molecular Weight 325.20300
Flash Point 276.4ºC
Exact Mass 324.02600
PSA 24.06000
LogP 5.41450
Index of Refraction 1.688
Precursor  2

DownStream  0