72103-53-8
72103-53-8 structure
| Name | Tuftsin diacetate |
|---|---|
| Synonyms |
tuftsin acetate salt hydrate
MFCD00133887 THR-LYS-PRO-ARG ACETATE SALT H-THR-LYS-PRO-ARG-OH ACOH tuftsin acetate H-THR-LYS-PRO-ARG-OH ACETATE SALT TUFTSIN ACETATE SALT Tuftsin Tuftsin (diacetate) |
| Description | Tuftsin diacetate, a tetrapeptide, is a macrophage/microglial activator. |
|---|---|
| Related Catalog | |
| In Vitro | Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages. Tuftsin's capacity to augment cellular activation is mediated by specific receptors that are identified, characterized, and recently isolated from rabbit peritoneal granulocytes[1]. Tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 Tcell (Th2) cytokine transcription factor GATA-3. Tuftsin promotes phagocytic activity for cells of monocytic origin, such as neutrophils, macrophages and microglia, all of which are thought to express Tuftsin receptors[2]. |
| References |
| Molecular Formula | C25H48N8O10 |
|---|---|
| Molecular Weight | 620.70 |
| PSA | 289.78000 |
| LogP | 0.53410 |
| Storage condition | 2-8℃ |
|
~54%
72103-53-8 |
| Literature: Dasgupta, S.; Chauhan, V. S. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1138 - 1141 |
|
~%
72103-53-8 |
| Literature: Dasgupta, S.; Chauhan, V. S. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1138 - 1141 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |