Name | 2-amino-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one |
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Synonyms |
5-(4-Hydroxy-benzylidene)-2-imino-thiazolidin-4-one
4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-, (5Z)- Mirin (5Z)-2-Amino-5-(4-hydroxybenzylidene)-1,3-thiazol-4(5H)-one 4-Thiazolidinone, 5-(p-hydroxybenzylidene)-2-imino- MRN-ATM Pathway Inhibitor,Mirin Lu AA 47070 |
Description | Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC50=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells[1]. |
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Related Catalog | |
In Vitro | Mirin inhibits H2AX phosphorylation with an IC50 of 66 μM. Mirin also inhibits the ATM-dependent phosphorylation of the downstream targets Nbs1 and Chk2 and the MRN-dependent autophosphorylation of ATM at Ser1981 in response to DSBs. Mirin induces a substantial G2 arrest at concentrations of 50 μM and 100 μM. Mirin (10-100 μM) inhibits homology-dependent DNA repair in TOSA4 cells[1]. BRCA2-deficient cells also showed hypersensitivity to the Mre11 inhibitor Mirin[2]. |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 441.6±55.0 °C at 760 mmHg |
Molecular Formula | C10H8N2O2S |
Molecular Weight | 220.248 |
Flash Point | 220.8±31.5 °C |
Exact Mass | 220.030655 |
PSA | 98.48000 |
LogP | 1.36 |
Vapour Pressure | 0.0±1.1 mmHg at 25°C |
Index of Refraction | 1.718 |
Storage condition | 2-8°C |
RIDADR | NONH for all modes of transport |
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HS Code | 2934999090 |
~62% 299953-00-7 |
Literature: Zhou, Jian-Feng; Sun, Xiao-Jun; Zhu, Feng-Xia; Li, Yan-Lun; Gong, Gui-Xia Synthetic Communications, 2008 , vol. 38, # 23 p. 4182 - 4187 |
HS Code | 2934999090 |
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Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |