Shanghai Nianxing Industrial Co., Ltd
China
Product Name: benzydamine
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Benzydamine
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642-72-8

642-72-8 structure

642-72-8 structure

Name: benzydamine
Chemical Name: 3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine
CAS Number: 642-72-8
Molecular Formula: C₁₉H₂₃N₃O
Molecular Weight: 309.405
Catalog: API Antipyretic analgesics Non-steroidal anti-inflammatory drugs
Create Date: 2018-07-10 11:23:43
Modify Date: 2025-08-21 08:41:58

Name	3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine
Synonyms	Benzydaminum [INN-Latin] Benzydamine [INN:BAN] Bencidamina [INN-Spanish] 1-Benzyl-3-[3-(dimethylamino)propoxy]-1H-indazole 1-Propanamine, N,N-dimethyl-3-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]- benzydamine C 1523 Benzidamina [DCIT] 1-Propanamine, N,N-dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)- benzidamine 1H-Indazole,1-benzyl-3-(3-(dimethylamino)propoxy) MFCD00864286 3-[(1-Benzyl-1H-indazol-3-yl)oxy]-N,N-dimethylpropan-1-amin 3-[(1-benzyl-1H-indazol-3-yl)oxy]-N,N-dimethylpropan-1-amine benzindamine EINECS 211-388-8 1-Benzyl-1H-indazol-3-yl 3-(Dimethylamino)propyl Ether [3-(1-benzyl-1H-indazol-3-yloxy)-propyl]-dimethyl-amine 3-[(1-Benzyl-1H-indazol-3-yl)oxy]-N,N-dimethyl-1-propanamine

Density	1.1±0.1 g/cm3
Boiling Point	474.4±35.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₃N₃O
Molecular Weight	309.405
Flash Point	240.7±25.9 °C
Exact Mass	309.184113
PSA	30.29000
LogP	3.78
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.580

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK7790000

CHEMICAL NAME :: 1H-Indazole, 1-benzyl-3-(3-(dimethylamino)propoxy)-

CAS REGISTRY NUMBER :: 642-72-8

BEILSTEIN REFERENCE NO. :: 0896536

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C19-H23-N3-O

MOLECULAR WEIGHT :: 309.45

WISWESSER LINE NOTATION :: T56 BNNJ B1R& DO3N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,41,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1266,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 109 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,471,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 445 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1285,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1285,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8925 mg/kg/21D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - changes in testicular weight

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,226,1972

HS Code	2933990090

Precursor 0
DownStream 1
37598-92-8

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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