Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Eterobarb
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27511-99-5

27511-99-5 structure

27511-99-5 structure

Name: Eterobarb
Chemical Name: Eterobarbital
CAS Number: 27511-99-5
Molecular Formula: C₁₆H₂₀N₂O₅
Molecular Weight: 320.34000
Catalog: Research Areas Neurological Disease
Create Date: 2018-04-16 08:00:00
Modify Date: 2024-01-11 19:50:03
Eterobarb (EX 12-095), a barbiturate derivative, is an anticonvulsant agent[1].

Name	Eterobarbital
Synonyms	5-ethyl-1,3-bis(methoxymethyl)-5-phenyl-1,3-diazinane-2,4,6-trione

Description	Eterobarb (EX 12-095), a barbiturate derivative, is an anticonvulsant agent[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Eterobarb (25 mg/kg, i.p.) increases the threshold for the clonic seizure in mice[1] Animal Model: Mice[1] Dosage: 25 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Increased the threshold for the clonic seizure by 1.75.degree.
References	[1]. R H Mattson, et al. Eterobarb therapy in epilepsy. Neurology. 1976 Nov;26(11):1014-7. [2]. R M Julien, et al. Effectiveness of N,N'-dimethoxymethylphenobarbital (eterobarbital) on febrile seizures. Proc West Pharmacol Soc. 1977;20:73-7.

Density	1.203g/cm3
Boiling Point	418.2ºC at 760mmHg
Melting Point	116-118ºC
Molecular Formula	C₁₆H₂₀N₂O₅
Molecular Weight	320.34000
Flash Point	206.7ºC
Exact Mass	320.13700
PSA	76.15000
LogP	1.20880
Vapour Pressure	3.34E-07mmHg at 25°C
Index of Refraction	1.526

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CQ0560000

CHEMICAL NAME :: Barbituric acid, 1,3-bis(methoxymethyl)-5-ethyl-5-phenyl-

CAS REGISTRY NUMBER :: 27511-99-5

BEILSTEIN REFERENCE NO. :: 0570278

LAST UPDATED :: 199703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H20-N2-O5

MOLECULAR WEIGHT :: 320.38

WISWESSER LINE NOTATION :: T6VNVNV FHJ B1O1 D1O1 F2 FR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 16,602,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 490 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4046894

HS Code	2933540000

HS Code	2933540000
Summary	2933540000 other derivatives of malonylurea (barbituric acid); salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%