Eterobarb

Modify Date: 2024-01-11 19:50:03

Eterobarb Structure
Eterobarb structure
Common Name Eterobarb
CAS Number 27511-99-5 Molecular Weight 320.34000
Density 1.203g/cm3 Boiling Point 418.2ºC at 760mmHg
Molecular Formula C16H20N2O5 Melting Point 116-118ºC
MSDS N/A Flash Point 206.7ºC

 Use of Eterobarb


Eterobarb (EX 12-095), a barbiturate derivative, is an anticonvulsant agent[1].

 Names

Name Eterobarbital
Synonym More Synonyms

 Eterobarb Biological Activity

Description Eterobarb (EX 12-095), a barbiturate derivative, is an anticonvulsant agent[1].
Related Catalog
In Vivo Eterobarb (25 mg/kg, i.p.) increases the threshold for the clonic seizure in mice[1] Animal Model: Mice[1] Dosage: 25 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Increased the threshold for the clonic seizure by 1.75.degree.
References

[1]. R H Mattson, et al. Eterobarb therapy in epilepsy. Neurology. 1976 Nov;26(11):1014-7.

[2]. R M Julien, et al. Effectiveness of N,N'-dimethoxymethylphenobarbital (eterobarbital) on febrile seizures. Proc West Pharmacol Soc. 1977;20:73-7.

 Chemical & Physical Properties

Density 1.203g/cm3
Boiling Point 418.2ºC at 760mmHg
Melting Point 116-118ºC
Molecular Formula C16H20N2O5
Molecular Weight 320.34000
Flash Point 206.7ºC
Exact Mass 320.13700
PSA 76.15000
LogP 1.20880
Vapour Pressure 3.34E-07mmHg at 25°C
Index of Refraction 1.526

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CQ0560000
CHEMICAL NAME :
Barbituric acid, 1,3-bis(methoxymethyl)-5-ethyl-5-phenyl-
CAS REGISTRY NUMBER :
27511-99-5
BEILSTEIN REFERENCE NO. :
0570278
LAST UPDATED :
199703
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C16-H20-N2-O5
MOLECULAR WEIGHT :
320.38
WISWESSER LINE NOTATION :
T6VNVNV FHJ B1O1 D1O1 F2 FR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 16,602,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
490 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4046894

 Safety Information

HS Code 2933540000

 Customs

HS Code 2933540000
Summary 2933540000 other derivatives of malonylurea (barbituric acid); salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

 Synonyms

5-ethyl-1,3-bis(methoxymethyl)-5-phenyl-1,3-diazinane-2,4,6-trione
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