Name | (s)-(-)-3-amino-1-hydroxypyrrolidin-2-one |
---|---|
Synonyms |
l-a-amino-e-n-benzyl-caprolactam
7-Nitroindazole |
Description | (S)-(-)-HA 966 ((-)-HA 966), a γ-Hydroxybutyrate-like agent, is weakly active as an NMDA-receptor antagonist. (S)-(-)-HA 966 possesses muscle relaxant action and prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear[1][2]. |
---|---|
Related Catalog | |
In Vitro | On cultured cortical neurones (+)-HA-966 inhibits glycine-potentiated NMDA responses with an IC50=13 μM compared with (-)-HA-966 (IC50=708 μM)[2]. |
In Vivo | (S)-(-)-HA 966 ((-)-HA 966; 3 and 5 mg/kg; i.p.) prevents restraint stress-induced dopamine utilization in both the medial prefrontal cortex and nucleus accumbens. (S)-(-)-HA 966 suppresses fear-induced behaviors: immobility and defecation[1]. (S)-(-)-HA 966 (3 mg/kg; i.p.) prevents locomotor sensitization without altering the acute motoric response elicited by cocaine[1]. (S)-(-)-HA 966 (5 mg/kg; i.p.) blocks acute cocaine-induced locomotion but resulted in sedation[1]. |
References |
Density | 1.436 g/cm3 |
---|---|
Boiling Point | 258.6ºC at 760 mmHg |
Molecular Formula | C4H8N2O2 |
Molecular Weight | 116.11900 |
Flash Point | 110.2ºC |
Exact Mass | 116.05900 |
PSA | 66.56000 |
~% 111821-58-0 |
Literature: Williams; Leeson; Hannah; Baker Journal of the Chemical Society - Series Chemical Communications, 1989 , # 22 p. 1740 - 1742 |
~98% 111821-58-0 |
Literature: Fushiya; Maeda; Funayama; Nozoe Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 480 - 483 |
Precursor 1 | |
---|---|
DownStream 0 |