53600-24-1

53600-24-1 structure

Name: 1-Hydroxyrutaecarpine
Chemical Name: 1-Hydroxy-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5( 7H)-one
CAS Number: 53600-24-1
Molecular Formula: C₁₈H₁₃N₃O₂
Molecular Weight: 303.31
Catalog: Natural product Alkaloid
Create Date: 2017-12-18 02:44:48
Modify Date: 2024-01-09 20:35:30
1-Hydroxyrutaecarpine (compound 1a) is a hydroxy-derivative of rutaecarpine. 1-Hydroxyrutaecarpine shows cytotoxicities with ED50s of 3.72, 7.44 µg/mL for P-388 and HT-29 cells, respectively. 1-Hydroxyrutaecarpine shows antiplatelet activity[1][2][3].

Name	1-Hydroxy-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5( 7H)-one
Synonyms	6-Methylmercapto-hexan-1-ol 7-thiaoctanol 1-hydroxyrutaecarpine Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro-1-hydroxy- 6-methylsulfanyl-hexan-1-ol 1-Hydroxy-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one 1-Hydroxy-7-thiaoctane

Description	1-Hydroxyrutaecarpine (compound 1a) is a hydroxy-derivative of rutaecarpine. 1-Hydroxyrutaecarpine shows cytotoxicities with ED50s of 3.72, 7.44 µg/mL for P-388 and HT-29 cells, respectively. 1-Hydroxyrutaecarpine shows antiplatelet activity[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Bruno Danieli; et al. 1-Hydroxyrutaecarpine from Euxylophora paraënsis. Phytochemistry, 1974 , 13(8), 1603–1606. [2]. Chen JJ, et al. New indolopyridoquinazoline, benzo[c]phenanthridines and cytotoxic constituents from Zanthoxylum integrifoliolum. Planta Med. 2005 May;71(5):470-5. [3]. Sheen WS, et al. Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum. Planta Med. 1996 Apr;62(2):175-6.