1320288-17-2
1320288-17-2 structure
- Name: UNC0646
- Chemical Name: N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
- CAS Number: 1320288-17-2
- Molecular Formula: C36H59N7O2
- Molecular Weight: 621.899
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2018-06-21 18:01:47
- Modify Date: 2024-01-29 11:56:58
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UNC0646 is a potent and selective G9a inhibitor with IC50 of 6 nM.IC50 value: 6 nM [1]Target: G9aUNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50 values are 6 nM and 15 nM for G9a and GLP, respectively). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50 = 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50 = 4.7 μM in MCF7 cells). UNC0646 is selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases.
| Name | N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine |
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| Synonyms |
N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine
Benzenemethanamine,N-(1-cyclohexylethylidene) N-(1-cyclohexylethylidene)benzylamine UNC0646 |
| Description | UNC0646 is a potent and selective G9a inhibitor with IC50 of 6 nM.IC50 value: 6 nM [1]Target: G9aUNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50 values are 6 nM and 15 nM for G9a and GLP, respectively). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50 = 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50 = 4.7 μM in MCF7 cells). UNC0646 is selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 754.6±70.0 °C at 760 mmHg |
| Molecular Formula | C36H59N7O2 |
| Molecular Weight | 621.899 |
| Flash Point | 410.1±35.7 °C |
| Exact Mass | 621.473022 |
| PSA | 72.46000 |
| LogP | 5.75 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.587 |
| Storage condition | 2-8℃ |
| RIDADR | NONH for all modes of transport |
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