59729-37-2

59729-37-2 structure

Name: Fexinidazole
Chemical Name: 1-methyl-2-[(4-methylsulfanylphenoxy)methyl]-5-nitroimidazole
CAS Number: 59729-37-2
Molecular Formula: C₁₂H₁₃N₃O₃S
Molecular Weight: 279.315
Catalog: Signaling Pathways Anti-infection Parasite
Create Date: 2018-09-04 20:54:13
Modify Date: 2024-01-08 09:50:09
Fexinidazole is a 5-nitroimidazole drug currently in clinical development for the treatment of human sleeping sickness (human African trypanosomiasis [HAT]), caused by infection with species of the protozoan parasite Trypanosoma brucei. Target: Antiparasiticin vivo: Fexinidazole shows dose-related efficacy in the T. b. rhodesiense (STIB900) acute mouse model at intraperitoneal (i.p.) doses of 20 to 50 mg/kg/day and oral (per os [p.o.]) doses of 25 to 100 mg/kg/day given on four consecutive days, with 100 mg/kg/day p.o. being 100% curative. Fexinidazole is shown to be effective in the GVR35 mouse model, which mimics the advanced and fatal stage of the disease, when parasites have disseminated into the brain. [1]

Name	1-methyl-2-[(4-methylsulfanylphenoxy)methyl]-5-nitroimidazole
Synonyms	1-Methyl-2-{[4-(methylsulfanyl)phenoxy]methyl}-5-nitro-1H-imidazole 1-methyl-2-(4-methylthiophenyl-oxymethyl)-5-nitro-imidazole 1-Methyl-2-((4-(methylthio)phenoxy)methyl)-5-nitro-1H-imidazole 1-methyl-2-(4-methylsulfanyl-phenoxymethyl)-5-nitro-1H-imidazole Fexinidazol Fexinidazole Fexinidazolum 1H-Imidazole, 1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro- 1-Methyl-2-((p-(methylthio)phenoxy)methyl)-5-nitroimidazole HOE-239

Description	Fexinidazole is a 5-nitroimidazole drug currently in clinical development for the treatment of human sleeping sickness (human African trypanosomiasis [HAT]), caused by infection with species of the protozoan parasite Trypanosoma brucei. Target: Antiparasiticin vivo: Fexinidazole shows dose-related efficacy in the T. b. rhodesiense (STIB900) acute mouse model at intraperitoneal (i.p.) doses of 20 to 50 mg/kg/day and oral (per os [p.o.]) doses of 25 to 100 mg/kg/day given on four consecutive days, with 100 mg/kg/day p.o. being 100% curative. Fexinidazole is shown to be effective in the GVR35 mouse model, which mimics the advanced and fatal stage of the disease, when parasites have disseminated into the brain. [1]
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. Kaiser M, et al. Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness. Antimicrob Agents Chemother. 2011 Dec;55(12):5602-8.

HS Code	2933290090

1073-72-9

6905-07-3

~58%

59729-37-2

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 3 p. 1015 - 1018

936-05-0

59729-37-2

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 3 p. 1015 - 1018

108-95-2

59729-37-2

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 3 p. 1015 - 1018

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%