Fexinidazole
Modify Date: 2024-01-08 09:50:09
Fexinidazole structure
|
Common Name | Fexinidazole | ||
|---|---|---|---|---|
| CAS Number | 59729-37-2 | Molecular Weight | 279.315 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 511.3±40.0 °C at 760 mmHg | |
| Molecular Formula | C12H13N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 263.0±27.3 °C | |
Use of FexinidazoleFexinidazole is a 5-nitroimidazole drug currently in clinical development for the treatment of human sleeping sickness (human African trypanosomiasis [HAT]), caused by infection with species of the protozoan parasite Trypanosoma brucei. Target: Antiparasiticin vivo: Fexinidazole shows dose-related efficacy in the T. b. rhodesiense (STIB900) acute mouse model at intraperitoneal (i.p.) doses of 20 to 50 mg/kg/day and oral (per os [p.o.]) doses of 25 to 100 mg/kg/day given on four consecutive days, with 100 mg/kg/day p.o. being 100% curative. Fexinidazole is shown to be effective in the GVR35 mouse model, which mimics the advanced and fatal stage of the disease, when parasites have disseminated into the brain. [1] |
| Name | 1-methyl-2-[(4-methylsulfanylphenoxy)methyl]-5-nitroimidazole |
|---|---|
| Synonym | More Synonyms |
| Description | Fexinidazole is a 5-nitroimidazole drug currently in clinical development for the treatment of human sleeping sickness (human African trypanosomiasis [HAT]), caused by infection with species of the protozoan parasite Trypanosoma brucei. Target: Antiparasiticin vivo: Fexinidazole shows dose-related efficacy in the T. b. rhodesiense (STIB900) acute mouse model at intraperitoneal (i.p.) doses of 20 to 50 mg/kg/day and oral (per os [p.o.]) doses of 25 to 100 mg/kg/day given on four consecutive days, with 100 mg/kg/day p.o. being 100% curative. Fexinidazole is shown to be effective in the GVR35 mouse model, which mimics the advanced and fatal stage of the disease, when parasites have disseminated into the brain. [1] |
|---|---|
| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 511.3±40.0 °C at 760 mmHg |
| Molecular Formula | C12H13N3O3S |
| Molecular Weight | 279.315 |
| Flash Point | 263.0±27.3 °C |
| Exact Mass | 279.067749 |
| PSA | 98.17000 |
| LogP | 2.28 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.629 |
| Storage condition | 2-8℃ |
| HS Code | 2933290090 |
|---|
|
~58%
Fexinidazole CAS#:59729-37-2 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 3 p. 1015 - 1018 |
|
~%
Fexinidazole CAS#:59729-37-2 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 3 p. 1015 - 1018 |
|
~%
Fexinidazole CAS#:59729-37-2 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 3 p. 1015 - 1018 |
![1-methyl-2-[(4-methylsulfinylphenoxy)methyl]-5-nitroimidazole structure](https://image.chemsrc.com/caspic/050/62351-99-9.png)
CAS#:62351-99-9| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 1-Methyl-2-{[4-(methylsulfanyl)phenoxy]methyl}-5-nitro-1H-imidazole |
| 1-methyl-2-(4-methylthiophenyl-oxymethyl)-5-nitro-imidazole |
| 1-Methyl-2-((4-(methylthio)phenoxy)methyl)-5-nitro-1H-imidazole |
| 1-methyl-2-(4-methylsulfanyl-phenoxymethyl)-5-nitro-1H-imidazole |
| Fexinidazol |
| Fexinidazole |
| Fexinidazolum |
| 1H-Imidazole, 1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro- |
| 1-Methyl-2-((p-(methylthio)phenoxy)methyl)-5-nitroimidazole |
| HOE-239 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Fexinidazole
- Price: Click To Check
- Purity: 99.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Fexinidazole
- Price: ￥376.0/25mg ￥1346.0/250mg ￥846.0/100mg ￥3366.0/1g
- Purity: 98.0%
- Delivery: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Fexinidazole (HOE-239)
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: Fexinidazole
- Price: $250.0/100mg $500.0/250mg $1000.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 1-METHYL-2-((4-(METHYLTHIO)PHENOXY)METHYL)-5-NITRO-1H-IMIDAZOLE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
Get all suppliers and price by the below link:
Price: ￥288.6/25mg
Reference only. check more Fexinidazole price