883050-24-6
883050-24-6 structure
- Name: CCG 50014
- Chemical Name: 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
- CAS Number: 883050-24-6
- Molecular Formula: C16H13FN2O2S
- Molecular Weight: 316.35000
- Catalog: Signaling Pathways GPCR/G Protein RGS Protein
- Create Date: 2017-03-02 04:16:37
- Modify Date: 2024-04-05 11:36:35
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CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site[1]. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test[2].
| Name | 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione |
|---|---|
| Synonyms |
2-p-tolyl-4-(4-fluorobenzyl)-1,2,4-thiadiazolidine-3,5-dione
UNII-RA72G28VE9 4-((4-fluorophenyl)methyl)-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione |
| Description | CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site[1]. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test[2]. |
|---|---|
| Related Catalog | |
| Target |
RGS4:30 nM (IC50) RGS8:11 μM (IC50) RGS16:3.5 μM (IC50) RGS19:0.12 μM (IC50) |
| In Vivo | CCG50014 (10, 30, or 100 nM) attenuates the nociceptive responses during the late phase in a dose-dependent manner[2]. |
| References |
| Molecular Formula | C16H13FN2O2S |
|---|---|
| Molecular Weight | 316.35000 |
| Exact Mass | 316.06800 |
| PSA | 72.24000 |
| LogP | 2.55650 |
| Storage condition | -20℃ |
| RIDADR | NONH for all modes of transport |
|---|
|
~39%
883050-24-6 |
| Literature: THE REGENTS OF THE UNIVERSITY OF MICHIGAN; Neubig, Richard; Blazer, Levi; Husbands, Stephen; Larsen, Scott; Traynor, John Patent: US2012/277273 A1, 2012 ; Location in patent: Page/Page column 22-23 ; |
