22350-41-0

22350-41-0 structure

Name: 5,6-trans-Vitamin D3
Chemical Name: 5,6-trans-Vitamin D3
CAS Number: 22350-41-0
Molecular Formula: C₂₇H₄₄O
Molecular Weight: 384.63800
Catalog: Signaling Pathways Vitamin D Related VD/VDR
Create Date: 2019-01-01 19:50:34
Modify Date: 2024-01-10 15:42:43
5,6-trans-Vitamin D3 (5,6-trans-Cholecalciferol;5,6-trans-Colecalciferol) is a photoproduct of vitamin D3[1]. Vitamin D3 is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

Name	5,6-trans-Vitamin D3
Synonyms	(3S,5E,7E)-9,10-Secocholesta-5,7,10-trien-3-ol

Description	5,6-trans-Vitamin D3 (5,6-trans-Cholecalciferol;5,6-trans-Colecalciferol) is a photoproduct of vitamin D3[1]. Vitamin D3 is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.
Related Catalog	Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease
In Vitro	Normal human keratinocytes in the cultured human keratinocytes by determining their influence on 3H-thymidine incorporation into DNA. 5,6-trans-vitamin D3 only induces significant inhibition at 10(-6) M. The dissociation constants of vitamin D receptor (VDR) for 5,6-trans-vitamin D3 is 560 nM[1].
References	[1]. T C Chen, et al. An evaluation of the biologic activity and vitamin D receptor binding affinity of the photoisomers of vitamin D3 and previtamin D3. J Nutr Biochem. 2000 May;11(5):267-72.