107429-63-0

107429-63-0 structure

Name: Lintopride
Chemical Name: 4-amino-5-chloro-N-[(1-ethyl-4,5-dihydroimidazol-2-yl)methyl]-2-methoxybenzamide
CAS Number: 107429-63-0
Molecular Formula: C₁₄H₁₉ClN₄O₂
Molecular Weight: 310.77900
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-06-21 16:47:28
Modify Date: 2024-01-20 22:34:47
Lintopride is a 5HT4 antagonist with moderate 5HT3 antagonist properties.

Name	4-amino-5-chloro-N-[(1-ethyl-4,5-dihydroimidazol-2-yl)methyl]-2-methoxybenzamide
Synonyms	UNII-C2R0GEU722 Lintopridum [INN-Latin] Lintoprida [INN-Spanish] Lintopridum Lintoprida Lintopride

Description	Lintopride is a 5HT4 antagonist with moderate 5HT3 antagonist properties.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
Target	5HT4[1]
In Vitro	Lintopride significantly increases the lower oesophageal sphincter basal tone without affecting lower oesophageal sphincter physiological relaxation after swallowing. Peristaltic waves are also enhanced by Lintopride[1].
References	[1]. Delvaux M, et al. The effects of lintopride, a 5HT-4 antagonist, on oesophageal motility. Aliment Pharmacol Ther. 1995 Oct;9(5):563-9.