109683-61-6

109683-61-6 structure

Name: Utibapril
Chemical Name: 5-tert-butyl-3-[2-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]propanoyl]-2H-1,3,4-thiadiazole-2-carboxylic acid
CAS Number: 109683-61-6
Molecular Formula: C₂₂H₃₁N₃O₅S
Molecular Weight: 449.56400
Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
Create Date: 2018-05-12 08:00:00
Modify Date: 2024-01-08 17:41:59
Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities.

Name	5-tert-butyl-3-[2-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]propanoyl]-2H-1,3,4-thiadiazole-2-carboxylic acid
Synonyms	Utibaprilo Utibaprilo [INN-Spanish] 5-tert-butyl-3-[n-(1-ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl]-2,3-dihydro-1,3,4-thiadiazole-2-carboxylic acid Utibapril Utibaprilum [INN-Latin] Utibaprilum 5-tert-butyl-3-{N-[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl}-2,3-dihydro-1,3,4-thiadiazole-2(S)-carboxylic acid

Description	Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease
In Vivo	Utibapril significantly inhibits plasma, renal, and vascular ACE but not ventricular ACE activity. Utibapril (2 μg/kg/day) significantly inhibits vascular ACE activity, and Utibapril (250 μg/kg/day) results in a significant inhibition of plasma ACE. Furthermore, angiotensin I-induced decreases in coronary flow in the isolated heart are significantly inhibited after treatment with the higher doses of utibapril[1]. FPL 63547 is rapidly and extensively excreted as the diacid in the bile but appeared in the urine in negligible amounts[2].
References	[1]. Buikema H, et al. Differential inhibition of plasma versus tissue ACE by utibapril: biochemical and functional evidence for inhibition of vascular ACE activity. J Cardiovasc Pharmacol. 1997 May;29(5):684-91. [2]. Carr RD, et al. Preferential biliary elimination of FPL 63547, a novel inhibitor of angiotensin-converting enzyme, in the rat. Br J Pharmacol. 1990 May;100(1):90-4.