Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (2S)-1-(1,2-Dioxo-3,3-dimethylpentyl)-2-pyrrolidinecarboxylic acid
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Purity: 98.0%
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186268-78-0

186268-78-0 structure

Name: GPI-1485
Chemical Name: (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylic acid
CAS Number: 186268-78-0
Molecular Formula: C₁₂H₁₉NO₄
Molecular Weight: 241.28400
Catalog: Research Areas Neurological Disease
Create Date: 2019-01-01 17:01:20
Modify Date: 2024-01-11 17:55:45
GPI-1485 (GM1485), a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke[1].

Name	(2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylic acid
Synonyms	(S)-methyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate UNII-0709BVY57W (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidincarboxylic acid GPI-1485 (2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-pyrrolidine-carboxylic acid

Description	GPI-1485 (GM1485), a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	GPI-1485 (GM1485; 100 μM) induces cellular reprogramming and neural cell induction in normal human dermal fibroblasts (NHDF)[1]. Cell Viability Assay[1] Cell Line: Normal human dermal fibroblasts (NHDF)[1] Concentration: 100 μM Incubation Time: Result: Induced cellular reprogramming and neural cell induction.
In Vivo	GPI-1485 (GM1485; 5 mg/kg; intraperitoneal injection; 6-week period of daily) improves long-term neurological recovery in rats[1]. Animal Model: Adult male Wistar rats, weighing 250-300 g[1] Dosage: 5 mg/kg Administration: Intraperitoneal injection; daily; for a total of 42 days Result: Administration improved neurological function and is consistent with an upregulation of endogenous neurogenesis following stroke in rats.
References	[1]. Andrew F Ducruet , et al. GM1485, a Nonimmunosuppressive Immunophilin Ligand, Promotes Neurofunctional Improvement and Neural Regeneration Following Stroke. J Neurosci Res. 2012 Jul;90(7):1413-23.

Hazard Codes	Xi
HS Code	2933990090

186268-77-9

~89%

186268-78-0

Literature: GPI Nil Holdings Inc. Patent: US7410995 B1, 2008 ; Location in patent: Page/Page column 29 ;

139419-63-9

186268-78-0

Literature: Journal of Medicinal Chemistry, , vol. 45, # 16 p. 3549 - 3557

1233885-04-5

186268-78-0

Literature: Journal of Medicinal Chemistry, , vol. 55, # 9 p. 4114 - 4122

Precursor 2
186268-77-9 139419-63-9
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%