1092502-33-4

1092502-33-4 structure

Name: GW 833972A
Chemical Name: 2-(3-chloroanilino)-N-(pyridin-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide,hydrochloride
CAS Number: 1092502-33-4
Molecular Formula: C₁₈H₁₄Cl₂F₃N₅O
Molecular Weight: 444.23800
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2017-02-23 20:50:24
Modify Date: 2024-09-16 19:52:01
GW 833972A is a selective CB2 receptor agonist. GW 833972A inhibits induced nerve depolarization and citric acid-induced cough in animal models[1].

Name	2-(3-chloroanilino)-N-(pyridin-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide,hydrochloride
Synonyms	2-[(3-chlorophenyl)amino]-N-(4-pyridinylmethyl)-4-(trifluoromethyl)-5-Pyrimidinecarboxamide hydrochloride

Description	GW 833972A is a selective CB2 receptor agonist. GW 833972A inhibits induced nerve depolarization and citric acid-induced cough in animal models[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	hCB2-R:7.3 (pEC50) rat CB2-R:7.5 (pEC50)
In Vitro	GW 833972A (0.3-300 μM; 10 min) 抑制辣椒素诱导的人和豚鼠去极化，还抑制前列腺素 E(2) 和高渗盐水诱导的豚鼠离体迷走神经去极化[1]。
In Vivo	GW 833972A (30 mg/kg, 2 mL/kg;腹腔注射; 单次剂量, 试验开始前 30 min 注射) 能够抑制柠檬酸诱导的有意识豚鼠的咳嗽症状。它还抑制辣椒素引起的主支气管血浆蛋白渗出现象[1]。
References	[1]. Belvisi MG, et al. Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways. Br J Pharmacol. 2008 Oct;155(4):547-57.