197431-02-0

197431-02-0 structure

Name: Debutyldronedarone hydrochloride
Chemical Name: Desbutyl Dronedarone Hydrochloride
CAS Number: 197431-02-0
Molecular Formula: C₂₇H₃₇ClN₂O₅S
Molecular Weight: 537.11100
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-10-10 12:13:35
Modify Date: 2024-01-14 10:13:51
Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic[1].

Name	Desbutyl Dronedarone Hydrochloride
Synonyms	N-[2-butyl-3-[4-[3-(butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide,hydrochloride Dronedarone Impurity 6

Description	Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Thyroid Hormone Receptor
Target	TRα1/TRβ1[1]
References	[1]. Van Beeren HC, et al. Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence. Endocrinology. 2003 Feb;144(2):552-8.

Hazard Codes	Xi