197431-02-0

197431-02-0 structure
197431-02-0 structure
  • Name: Debutyldronedarone hydrochloride
  • Chemical Name: Desbutyl Dronedarone Hydrochloride
  • CAS Number: 197431-02-0
  • Molecular Formula: C27H37ClN2O5S
  • Molecular Weight: 537.11100
  • Catalog: Research Areas Cardiovascular Disease
  • Create Date: 2018-10-10 12:13:35
  • Modify Date: 2024-01-14 10:13:51
  • Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic[1].

Name Desbutyl Dronedarone Hydrochloride
Synonyms N-[2-butyl-3-[4-[3-(butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide,hydrochloride
Dronedarone Impurity 6
Description Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic[1].
Related Catalog
Target

TRα1/TRβ1[1]

References

[1]. Van Beeren HC, et al. Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence. Endocrinology. 2003 Feb;144(2):552-8.

Molecular Formula C27H37ClN2O5S
Molecular Weight 537.11100
Exact Mass 536.21100
PSA 106.02000
LogP 7.88320
Hazard Codes Xi