Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4,6-Dichloroisatin
Price: ￥448.0/1g ￥188.0/250mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4,6-Dichloro-1H-indole-2,3-dione
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 4,6-DICHLORO-1H-INDOLE-2,3-DIONE
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

18711-15-4

18711-15-4 structure

18711-15-4 structure

Name: 4,6-Dichloroisatin
Chemical Name: 4,6-dichloro-1h-indole-2,3-dione
CAS Number: 18711-15-4
Molecular Formula: C₈H₃Cl₂NO₂
Molecular Weight: 216.02
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2018-04-17 08:00:00
Modify Date: 2024-01-12 18:31:43
CFL-120 is a potent KRasG12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer[1].

Name	4,6-dichloro-1h-indole-2,3-dione
Synonyms	4,6-dichloro-2,3-dihydro-1H-indole-2,3-dione 1H-indole-2,3-dione, 4,6-dichloro- 4,6-dichloroisatine 4,6-DICHLORO-1H-INDOLE-2,3-DIONE 4,6-dichloroindolin-2,3-dione 4,6-Dichlor-indolin-2,3-dion 4,6-dichloroisatin 4,6-dichloro-indoline-2,3-dione

Description	CFL-120 is a potent KRasG12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRAS(G12C)
In Vitro	CFL-120 (72 h) 显示出抗增殖作用，对 H1792, SW1573, MiaPaca2, H358, A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, CCD-986Sk 细胞的 IC50 值分别为 111.0, 23.6, 13.7, 16.9, 44.4, 14.8, 38.0, 30.0, 13.1, 9.8, 47.9, 24.4, 42.7 µM[1]。
In Vivo	CFL-120 (5 mg/kg，5 次治疗；15 mg/kg，5 次治疗；30 mg/kg，3 次治疗；i.p.) 减少皮下人肺癌 H1792 (KRasG12C 突变体) 和 LCLC-103H (KRasWT) 小鼠肿瘤模型的生长[1]。 Animal Model: NOD/SCID female mice (KRasWT (LCLC-103H) or KRasG12C (H1792) tumors)[1] Dosage: 5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments Administration: I.p. Result: Reduced tumor growth compared to the control group in KRasG12C mutated model for 35.8%.
References	[1]. Orgován Z, et al. Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency. Eur J Med Chem. 2023 Mar 15;250:115212.

Density	1.6±0.1 g/cm3
Melting Point	260.5-261°C
Molecular Formula	C₈H₃Cl₂NO₂
Molecular Weight	216.02
Exact Mass	214.954086
PSA	46.17000
LogP	2.20
Index of Refraction	1.638

Hazard Codes	T+
RIDADR	2811.0
HS Code	2933990090

18711-11-0 structure

18711-11-0

~97%

18711-15-4 structure

18711-15-4

Literature: Seong, Churl Min; Park, Woo Kyu; Park, Chul Min; Kong, Jae Yang; Park, No Sang Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 738 - 743

75-87-6 structure

75-87-6

626-43-7 structure

626-43-7

~%

18711-15-4 structure

18711-15-4

Literature: US6576656 B1, ;

626-43-7 structure

626-43-7

~%

18711-15-4 structure

18711-15-4

Literature: Helvetica Chimica Acta, , vol. 2, p. 239

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%