Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Praziquantel
Price: ￥328.0/5g ￥568.0/100g ￥248.0/25g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Praziquantel (Biltricide)
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Praziquantel
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Praziquantel
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Praziquantel
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

55268-74-1

55268-74-1 structure

Name: Praziquantel
Chemical Name: Praziquantel
CAS Number: 55268-74-1
Molecular Formula: C₁₉H₂₄N₂O₂
Molecular Weight: 312.406
Catalog: API Antiparasitic drug Anti-fungal medicine
Create Date: 2018-02-07 08:00:00
Modify Date: 2024-01-02 13:40:51
Praziquantel is an anthelmintic effective against flatworms.Target: AntiparasiticPraziquantel is the drug of choice for treatment of all human schistosomes. Infected mice were treated with increasing Praziquantel doses until the highest dose of 3 × 300 mg/Kg was reached. The effect of Praziquantel treatment on the parasite population was assessed using five polymorphic microsatellite markers. Parasitological and genetic data were compared with those of the untreated control. After six parasite generations submitted to treatment, it was possible to obtain a S. mansoni population with decreased susceptibility to Praziquantel. In our experiments we also observed that female worms were more susceptible to Praziquantel than male worms [1, 2].

Name	Praziquantel
Synonyms	Distocide WarMnil embay8440 droncit rac-praziquantel Prazinon Cesol biltricide EINECS 259-559-6 Azinox MFCD00058531 Cysticide pyquiton 2-CYCLOHEXYL-CARBONYL-1,3,4,6,7,11B-HEXAHYDRO-2H-PYRAZINE (2,1-A)ISOQUINOLINE-4-ONE

Description	Praziquantel is an anthelmintic effective against flatworms.Target: AntiparasiticPraziquantel is the drug of choice for treatment of all human schistosomes. Infected mice were treated with increasing Praziquantel doses until the highest dose of 3 × 300 mg/Kg was reached. The effect of Praziquantel treatment on the parasite population was assessed using five polymorphic microsatellite markers. Parasitological and genetic data were compared with those of the untreated control. After six parasite generations submitted to treatment, it was possible to obtain a S. mansoni population with decreased susceptibility to Praziquantel. In our experiments we also observed that female worms were more susceptible to Praziquantel than male worms [1, 2].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. Coeli, R., et al., Praziquantel treatment decreases Schistosoma mansoni genetic diversity in experimental infections. PLoS Negl Trop Dis, 2013. 7(12): p. e2596. [2]. Mekonnen, A., et al., Efficacy of Praziquantel against Schistosoma haematobium in Dulshatalo village, western Ethiopia. BMC Res Notes, 2013. 6: p. 392.

Density	1.2±0.1 g/cm3
Boiling Point	544.1±50.0 °C at 760 mmHg
Melting Point	136-142ºC
Molecular Formula	C₁₉H₂₄N₂O₂
Molecular Weight	312.406
Flash Point	254.6±22.5 °C
Exact Mass	312.183777
PSA	40.62000
LogP	2.44
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.615
Water Solubility	ethanol: soluble5mg/mL \| Freely soluble in ethanol or dichloromethane. Slightly soluble in water

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ4150000

CHEMICAL NAME :: 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-

CAS REGISTRY NUMBER :: 55268-74-1

BEILSTEIN REFERENCE NO. :: 0761557

LAST UPDATED :: 199710

DATA ITEMS CITED :: 22

MOLECULAR FORMULA :: C19-H24-N2-O2

MOLECULAR WEIGHT :: 312.45

WISWESSER LINE NOTATION :: T B666 DN FVNTT&J DV- AL6TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2840 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 586 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >16 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2454 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 376 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7172 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - hamster Liver

DOSE/DURATION :: 2700 umol/L

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 46,461,1990 *** REVIEWS *** TOXICOLOGY REVIEW CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915- Suspended 1967-72. Volume(issue)/page/year: 61,52,1981

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F: Flammable;C: Corrosive;
Risk Phrases	R11
Safety Phrases	16-26-36/37/39-45
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	UQ4150000
HS Code	2933790090

Precursor 7
79848-93-4 79-04-9 2719-27-9 61196-37-0
2043-61-0 87693-75-2 98-89-5
DownStream 3
5234-86-6 61196-37-0 61196-40-5

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

55268-74-1	57452-31-0
57452-98-9	57452-97-8
1246343-36-1	79802-20-3
1399880-38-6	60743-58-0
125273-86-1	134924-68-8