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55268-74-1

55268-74-1 structure
55268-74-1 structure
  • Name: Praziquantel
  • Chemical Name: Praziquantel
  • CAS Number: 55268-74-1
  • Molecular Formula: C19H24N2O2
  • Molecular Weight: 312.406
  • Catalog: API Antiparasitic drug Anti-fungal medicine
  • Create Date: 2018-02-07 08:00:00
  • Modify Date: 2026-06-30 10:25:31
  • Praziquantel is an anthelmintic effective against flatworms.Target: AntiparasiticPraziquantel is the drug of choice for treatment of all human schistosomes. Infected mice were treated with increasing Praziquantel doses until the highest dose of 3 × 300 mg/Kg was reached. The effect of Praziquantel treatment on the parasite population was assessed using five polymorphic microsatellite markers. Parasitological and genetic data were compared with those of the untreated control. After six parasite generations submitted to treatment, it was possible to obtain a S. mansoni population with decreased susceptibility to Praziquantel. In our experiments we also observed that female worms were more susceptible to Praziquantel than male worms [1, 2].
Name Praziquantel
Synonyms Praziquintel (FDA)
droncit
Praziguantel
Praziquantel25
2-[CYCLOHEXYLCBONYL]-1,2,3,6,B-HEXAHYDRO-4H-PYRAZINO[2,1A]ISOQUINOLIN-4-ONE
PRAZIQUANTEL
Acetylchloride,2-[8-(trifluoromethyl)phenoxy]
Cesol
biltricide
Ethidium bromide 1-8
WMnil
Cysticide
Praziquantel //BP
PRAZIQUANTEL VETRANAL
Praziquantel CRS
Praziquantel in dichloromethane
Praziquantel Standd
Praziquantel Solution in Acetonitrile
4h-pyrazino(2,1-a)isoquinolin-4-one,2-(cyclohexylcbonyl)-1,2,3,6,7,11b-hexah
embay8440
Praziquantel Powder
Praziquantel for system suitability CRS
Praziquentel
Praziquantel for system suitability
1-a]-isoquinolin-4-one,2-(cyclohexylcbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2
EINECS -6
2-(Cyclohexanecbonyl)-1，3，4，6，7，11b-hexahydro-4H-pyrazino[2，1-α]isoquinolin-4-one
praz,quantel
2-cyclohexyl-carbonyl-1,3,4,6,7,11b-hexahydro-2h-pyrazine(2,1-a)isoquinoline-4-one
PRAZIQUANTEL BP 98
WarMnil
4H-pyrazino-[2,1-a]-isoquinolin-4-one,2-(cyclohexylcbonyl)-1,2,3,6,7,11b-hexahydro
Praziquantel in Methanol
Phmaceutical Praziquantel
Usnea diffract
Prazinon
2-(CYCLOHEXYLCBONYL)-1,2,3,6,BETA-HEXAHYDRO-4H-PYRAZINO[2,1A] ISOQUINOLIN-4-ONE
Praziquantel Powder Praziquantel manufacture
EINECS 259-559-6
Praziquantel in acetonitrile
4H-Pyrazino[2,1-a]isoquinolin-4-one, 2-(cyclohexylcbonyl)-1,2,3,6,7,11b-hexahydro- (9CI)
Praziquantel, Pyquiton
2-(cyclohexanecbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one
2-CYCLOHEXYL-CARBONYL-1,3,4,6,7,11B-HEXAHYDRO-2H-PYRAZINE (2,1-A)ISOQUINOLINE-4-ONE
Distocide
2-cyclohexylcbonyl-1,2,3,6,7,11b-hexahydro-4h-pyrazino(2,1-a)isoquinolin-4
Praziquantel (10mM in DMSO)
rac-praziquantel
Praziquantel (Biltricide)
PRAZIQUANTEL F&D VERSION
Prazichantel
Factory Supply/Vermifuge/ /Praziquantel/CAS55-1/with Best Price/White Crystalline Powder/Pesticides and Dye Intermediates
Praziquantel>
Praziquantel RS
Drontal
Azinox
MFCD00058531
Praziquantel 100 μg/mL in Acetonitrile
pyquiton
(11bS)-2-cyclohexanecbonyl-1H,2H,3H,4H,6H,7H,11bH-piperazino[2,1-a]isoquinolin-4-one
Description Praziquantel is an anthelmintic effective against flatworms.Target: AntiparasiticPraziquantel is the drug of choice for treatment of all human schistosomes. Infected mice were treated with increasing Praziquantel doses until the highest dose of 3 × 300 mg/Kg was reached. The effect of Praziquantel treatment on the parasite population was assessed using five polymorphic microsatellite markers. Parasitological and genetic data were compared with those of the untreated control. After six parasite generations submitted to treatment, it was possible to obtain a S. mansoni population with decreased susceptibility to Praziquantel. In our experiments we also observed that female worms were more susceptible to Praziquantel than male worms [1, 2].
Related Catalog
References

[1]. Coeli, R., et al., Praziquantel treatment decreases Schistosoma mansoni genetic diversity in experimental infections. PLoS Negl Trop Dis, 2013. 7(12): p. e2596.

[2]. Mekonnen, A., et al., Efficacy of Praziquantel against Schistosoma haematobium in Dulshatalo village, western Ethiopia. BMC Res Notes, 2013. 6: p. 392.
Density 1.2±0.1 g/cm3
Boiling Point 544.1±50.0 °C at 760 mmHg
Melting Point 136-142ºC
Molecular Formula C19H24N2O2
Molecular Weight 312.406
Flash Point 254.6±22.5 °C
Exact Mass 312.183777
PSA 40.62000
LogP 2.44
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.615
Water Solubility ethanol: soluble5mg/mL | Freely soluble in ethanol or dichloromethane. Slightly soluble in water

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ4150000
CHEMICAL NAME :
4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-
CAS REGISTRY NUMBER :
55268-74-1
BEILSTEIN REFERENCE NO. :
0761557
LAST UPDATED :
199710
DATA ITEMS CITED :
22
MOLECULAR FORMULA :
C19-H24-N2-O2
MOLECULAR WEIGHT :
312.45
WISWESSER LINE NOTATION :
T B666 DN FVNTT&J DV- AL6TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2840 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
586 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>16 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2454 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
376 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7172 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1050 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - hamster Liver
DOSE/DURATION :
2700 umol/L
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 46,461,1990 *** REVIEWS *** TOXICOLOGY REVIEW CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915- Suspended 1967-72. Volume(issue)/page/year: 61,52,1981
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F: Flammable;C: Corrosive;
Risk Phrases R11
Safety Phrases 16-26-36/37/39-45
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS UQ4150000
HS Code 2933790090
HS Code 2933790090
Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%
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