83602-05-5

83602-05-5 structure

Name: Spiraprilat
Chemical Name: (8S)-7-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
CAS Number: 83602-05-5
Molecular Formula: C₂₀H₂₆N₂O₅S₂
Molecular Weight: 438.56100
Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
Create Date: 2017-05-16 17:09:23
Modify Date: 2026-07-09 11:02:01
Spiraprilat is a potent angiotensin-converting enzyme (ACE) inhibitor. Spiraprilat has ability to improve left ventricular (LV) function and metabolism in anesthetized open-chest dogs with acute ventricular failure (ALVF)[1].

Name	(8S)-7-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
Synonyms	Spiraprilatum UNII-QS56V5Y7EC (8S)-7-[(2S)-2-[[(1S)-1-Cboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,4-dithia-7-azaspirononane-8-cboxylic acid (3S)-2-[(S)-2-[[(S)-1-Cboxy-3-phenylpropyl]amino]propionyl]-2-aza-6,9-dithiaspirononane-3-cboxylic acid Spiraprilate [inn-french] SPIRAPRILAT Spiraprilatum [inn-latin] Spiraprilate 1,4-Dithia-7-azaspirononane-8-cboxylic acid, 7-(2-((1-cboxy-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R(R)),8R*)) TI-213-864

Description	Spiraprilat is a potent angiotensin-converting enzyme (ACE) inhibitor. Spiraprilat has ability to improve left ventricular (LV) function and metabolism in anesthetized open-chest dogs with acute ventricular failure (ALVF)[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
References	[1]. Nakazawa M, et al. Effects of spiraprilat, an angiotensin-converting enzyme inhibitor, on anesthetized dogs in a new model of acute left ventricular failure. J Cardiovasc Pharmacol. 1993 Oct;22(4):585-93.