180851-50-7

180851-50-7 structure

Name: Tos-O-C4-NH-Boc
Chemical Name: 4-[(2-methylpropan-2-yl)oxycarbonylamino]butyl 4-methylbenzenesulfonate
CAS Number: 180851-50-7
Molecular Formula: C₁₆H₂₅NO₅S
Molecular Weight: 343.43800
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-01-15 22:57:59
Modify Date: 2025-08-27 15:12:35
Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 (HY-136250)[1].

Name	4-[(2-methylpropan-2-yl)oxycarbonylamino]butyl 4-methylbenzenesulfonate
Synonyms	Toluene-4-sulfonic acid 4-tert-butoxy-carbonylamino-butyl ester

Description	Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 (HY-136250)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21.