909880-81-5

909880-81-5 structure

Name: Levothyroxine acyl glucuronide
Chemical Name: (2S,3S,4S,5R,6S)-6-[(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoyl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
CAS Number: 909880-81-5
Molecular Formula: C₂₁H₁₉I₄NO₁₀
Molecular Weight: 952.99400
Catalog: Research Areas Metabolic Disease
Create Date: 2017-09-04 10:02:40
Modify Date: 2024-01-12 18:13:01
Levothyroxine acyl glucuronide (Thyroxine Acyl-β-D-glucuronide), an endogenous metabolite, is the acyl glucuronide formation of thyroxine (T4)[1].

Name	(2S,3S,4S,5R,6S)-6-[(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoyl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Synonyms	Levothyroxine Acyl Glucuronide Thyroxine Glucuronoside Thyroxine Acyl-\|A-D-Glucuronide

Description	Levothyroxine acyl glucuronide (Thyroxine Acyl-β-D-glucuronide), an endogenous metabolite, is the acyl glucuronide formation of thyroxine (T4)[1].
Related Catalog	Research Areas >> Metabolic Disease
Target	Endogenous metabolite[1]
In Vitro	Levothyroxine acyl glucuronide is a metabolite of T4 glucuronides after hydrolysis with β-glucuronidase[1].
References	[1]. Tong Z, et al. In vitro glucuronidation of thyroxine and triiodothyronine by liver microsomes and recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2007 Dec;35(12):2203-10.