864681-04-9

864681-04-9 structure

Name: Azido-PEG4-CH2-Boc
Chemical Name: 3,6,9,12-Tetraoxatetradecanoic acid, 14-azido-, 1,1-dimethylethyl ester
CAS Number: 864681-04-9
Molecular Formula: C₁₄H₂₇N₃O₆
Molecular Weight: 333.38100
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2017-01-07 07:59:16
Modify Date: 2024-01-10 20:26:14
Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Name	3,6,9,12-Tetraoxatetradecanoic acid, 14-azido-, 1,1-dimethylethyl ester
Synonyms	tert-Butyl 14-azido-3,6,9,12-tetraoxatetradecanoate

Description	Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Shiladitya Sengupta, et al. Targeted drug delivery through affinity based linkers. WO2015148126A1. [2]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.