Azido-PEG4-CH2-Boc
Modify Date: 2024-01-10 20:26:14
Azido-PEG4-CH2-Boc structure
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Common Name | Azido-PEG4-CH2-Boc | ||
|---|---|---|---|---|
| CAS Number | 864681-04-9 | Molecular Weight | 333.38100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H27N3O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Azido-PEG4-CH2-BocAzido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
| Name | 3,6,9,12-Tetraoxatetradecanoic acid, 14-azido-, 1,1-dimethylethyl ester |
|---|---|
| Synonym | More Synonyms |
| Description | Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
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| Related Catalog | |
| Target |
PEGs Alkyl/ether Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
[1]. Shiladitya Sengupta, et al. Targeted drug delivery through affinity based linkers. WO2015148126A1. |
| Molecular Formula | C14H27N3O6 |
|---|---|
| Molecular Weight | 333.38100 |
| Exact Mass | 333.19000 |
| PSA | 112.97000 |
| LogP | 1.15756 |
| Storage condition | -20°C |
| tert-Butyl 14-azido-3,6,9,12-tetraoxatetradecanoate |