Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Malaoxon
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Malaoxon
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1634-78-2

1634-78-2 structure

Name: Malaoxon
Chemical Name: diethyl 2-dimethoxyphosphorylsulfanylbutanedioate
CAS Number: 1634-78-2
Molecular Formula: C₁₀H₁₉O₇PS
Molecular Weight: 314.292
Catalog: Chemical pesticide Insecticide Organochlorine insecticide
Create Date: 2018-02-11 08:00:00
Modify Date: 2024-01-11 18:15:17
Malaoxon is a pesticide metabolite. Malaoxon can induce cellular death in cultured human pulmonary cells. Malaoxon can be used for the research of pulmonary toxicity[1].

Name	diethyl 2-dimethoxyphosphorylsulfanylbutanedioate
Synonyms	diethyl 2-[(dimethoxyphosphoryl)thio]succinate Malathion impurity B Liromat Diethyl-2-[(dimethoxyphosphoryl)sulfanyl]butandioat Malathion-O-analog dimethoxyphosphorylsulfanyl-succinic acid diethyl ester Maloxon rac-malaoxon diethyl 2-[(dimethoxyphosphoryl)sulfanyl]butanedioate Diethyl 2-[(dimethoxyphosphoryl)sulfanyl]succinate Butanedioic acid, 2-[(dimethoxyphosphinyl)thio]-, diethyl ester Dimethoxyphosphorylmercapto-bernsteinsaeure-diaethylester MFCD00055461 Butanedioic acid, [(dimethoxyphosphinyl)thio]-, diethyl ester Malaoxone Oxycarbophos Carbethoxy malaoxon Malaoxon

Description	Malaoxon is a pesticide metabolite. Malaoxon can induce cellular death in cultured human pulmonary cells. Malaoxon can be used for the research of pulmonary toxicity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. Angelini DJ, et al. The Pesticide Metabolites Paraoxon and Malaoxon Induce Cellular Death by Different Mechanisms in Cultured Human Pulmonary Cells. Int J Toxicol. 2015 Sep-Oct;34(5):433-41.

Density	1.2±0.1 g/cm3
Boiling Point	376.0±52.0 °C at 760 mmHg
Melting Point	<20℃
Molecular Formula	C₁₀H₁₉O₇PS
Molecular Weight	314.292
Flash Point	181.2±30.7 °C
Exact Mass	314.058899
PSA	123.24000
LogP	2.07
Appearance	liquid
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.470

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WM8410000

CHEMICAL NAME :: Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethylphosphorothioate

CAS REGISTRY NUMBER :: 1634-78-2

LAST UPDATED :: 199806

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C10-H19-O7-P-S

MOLECULAR WEIGHT :: 314.32

WISWESSER LINE NOTATION :: 2OV1YVO2&SPO&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 158 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 215 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 119 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 8200 ug/kg

SEX/DURATION :: female 18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 100 umol/L

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 8,939,1981

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H310
Precautionary Statements	Missing Phrase - N15.00950417-P262-P280-P302 + P352 + P310-P361 + P364
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	F,Xn,N,T
Risk Phrases	11-38-50/53-65-67-24/25
Safety Phrases	60-61-62-45-36/37/39-46-37-24
RIDADR	UN 3018
RTECS	WM8410000
Packaging Group	III
Hazard Class	6.1(b)

121-75-5

1634-78-2

Literature: US2713018 , ;

23060-14-2

1634-78-2

Literature: Journal of Organic Chemistry, , vol. 30, p. 1074 - 1077

2090-25-7

121-45-9

1634-78-2

Literature: Journal of Organic Chemistry, , vol. 30, p. 1074 - 1077

Precursor 3
121-75-5 23060-14-2 121-45-9
DownStream 0

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