23205-42-7

23205-42-7 structure

Name: 3-Deazauridine
Chemical Name: 3-Deazauridine
CAS Number: 23205-42-7
Molecular Formula: C₁₀H₁₃NO₆
Molecular Weight: 243.21
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2018-11-20 19:36:34
Modify Date: 2024-01-12 17:34:55
3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier[1].

Name	3-Deazauridine
Synonyms	3-deazauridine EINECS 245-488-8 MFCD00006522

Description	3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Target	Cytidine triphosphate synthase[1]
In Vitro	3-Deazauridine (DAUR) 对 L1210 白血病细胞具有优异的抗肿瘤活性[1]。
In Vivo	3-Deazauridine (DAUR) (250 mg/kg/天；腹腔注射；1-9 天) 对小鼠中的 L1210 白血病细胞显示出中等活性[1]。 3-Deazauridine (腹腔注射；给药 5 次) 对比格犬和恒河猴的致死剂量分别为 250 mg/kg/day 和 417 mg/kg/day，最低毒性剂量为 62.5 mg/kg/day 和 104 mg/kg/day，无毒剂量分别为 31.25 mg/kg/day 和 52 mg/kg/day[1]。
References	[1]. Moriconi WJ, et al. 3-Deazauridine (NSC 126849): an interesting modulator of biochemical response. Invest New Drugs. 1986;4(1):67-84.

REFERENCE :: PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,295,1983

RTECS	UV1148000

23220-74-8

23205-42-7

6974-32-9

23205-42-7

626-03-9

23205-42-7

Precursor 3
23220-74-8 6974-32-9 626-03-9
DownStream 0