3-Deazauridine

Modify Date: 2024-01-12 17:34:55

3-Deazauridine structure	Common Name	3-Deazauridine
	CAS Number	23205-42-7	Molecular Weight	243.21
	Density	1.718g/cm3	Boiling Point	528ºC at 760mmHg
	Molecular Formula	C₁₀H₁₃NO₆	Melting Point	233-235ºC
	MSDS	N/A	Flash Point	273.1ºC

Use of 3-Deazauridine

3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier[1].

Name	3-Deazauridine
Synonym	More Synonyms

Description	3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Target	Cytidine triphosphate synthase[1]
In Vitro	3-Deazauridine (DAUR) 对 L1210 白血病细胞具有优异的抗肿瘤活性[1]。
In Vivo	3-Deazauridine (DAUR) (250 mg/kg/天；腹腔注射；1-9 天) 对小鼠中的 L1210 白血病细胞显示出中等活性[1]。 3-Deazauridine (腹腔注射；给药 5 次) 对比格犬和恒河猴的致死剂量分别为 250 mg/kg/day 和 417 mg/kg/day，最低毒性剂量为 62.5 mg/kg/day 和 104 mg/kg/day，无毒剂量分别为 31.25 mg/kg/day 和 52 mg/kg/day[1]。
References	[1]. Moriconi WJ, et al. 3-Deazauridine (NSC 126849): an interesting modulator of biochemical response. Invest New Drugs. 1986;4(1):67-84.

Density	1.718g/cm3
Boiling Point	528ºC at 760mmHg
Melting Point	233-235ºC
Molecular Formula	C₁₀H₁₃NO₆
Molecular Weight	243.21
Flash Point	273.1ºC
Exact Mass	243.07400
PSA	112.15000
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.706

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV1148000

CHEMICAL NAME :: 2(1H)-Pyridone, 4-hydroxy-1-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 23205-42-7

LAST UPDATED :: 199206

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H13-N-O6

MOLECULAR WEIGHT :: 243.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 1 nmol

REFERENCE :: PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,295,1983

RTECS	UV1148000

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Precursor 3
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DownStream 0

3-deazauridine

EINECS 245-488-8

MFCD00006522

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3-Deazauridine
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Purity: 98.0%
Delivery: 10 Day
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DC Chemicals Limited
China
Product Name: 3-Deazauridine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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3-Deazauridine

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