796073-55-7
796073-55-7 structure
- Name: 4-Methyl-4-(methyldisulfanyl)pentanoicacid
- Chemical Name: 4-methyl-4-(methyldisulfanyl)pentanoic acid
- CAS Number: 796073-55-7
- Molecular Formula: C7H14O2S2
- Molecular Weight: 194.31500
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2016-01-10 19:30:29
- Modify Date: 2024-01-03 19:51:45
-
4-Methyl-4-(methyldisulfanyl)pentanoic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
| Name | 4-methyl-4-(methyldisulfanyl)pentanoic acid |
|---|---|
| Synonyms |
4-methyl-4-(methyldithio)pentanoic acid
Pentanoic acid,4-methyl-4-(methyldithio) 4-methyl-4-methyldisulfanylpentanoic acid 4-methyldithio-4-methyl-pentanoic acid |
| Description | 4-Methyl-4-(methyldisulfanyl)pentanoic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. |
| References |
| Molecular Formula | C7H14O2S2 |
|---|---|
| Molecular Weight | 194.31500 |
| Exact Mass | 194.04400 |
| PSA | 87.90000 |
| LogP | 2.64100 |
|
~82%
796073-55-7 |
| Literature: Zhao, Robert Yongxin; Erickson, Hans K.; Leece, Barbara A.; Reid, Emily E.; Goldmacher, Victor S.; Lambert, John M.; Chari, Ravi V. J. Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 766 - 782 |
|
~%
796073-55-7 |
| Literature: Widdison, Wayne C.; Wilhelm, Sharon D.; Cavanagh, Emily E.; Whiteman, Kathleen R.; Leece, Barbara A.; Kovtun, Yelena; Goldmacher, Victor S.; Xie, Hongsheng; Steeves, Rita M.; Lutz, Robert J.; Zhao, Robert; Wang, Lintao; Blaettler, Walter A.; Chari, Ravi V. J. Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4392 - 4408 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |