102783-47-1

102783-47-1 structure

Name: N,O-Didansyl-L-tyrosine cyclohexylammonium salt
Chemical Name: N,O-Didansyl-L-tyrosine cyclohexylammonium salt
CAS Number: 102783-47-1
Molecular Formula: C₃₉H₄₆N₄O₇S₂
Molecular Weight: 746.93500
Catalog: Signaling Pathways Apoptosis Thymidylate Synthase
Create Date: 2017-08-19 13:02:39
Modify Date: 2024-01-10 17:49:08
N,O-Didansyl-L-tyrosine cyclohexylammonium is a potent selective thymidylate synthase (TS) inhibitor，acts on TS of Escherichia coli, Lactobacillus casei and human with the IC50 values of 5.0, 3.4 and 119 μM, respectively[1].

Name	N,O-Didansyl-L-tyrosine cyclohexylammonium salt
Synonyms	cyclohexanamine,(2S)-2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]-3-[4-[5-(dimethylamino)naphthalen-1-yl]sulfonyloxyphenyl]propanoic acid

Description	N,O-Didansyl-L-tyrosine cyclohexylammonium is a potent selective thymidylate synthase (TS) inhibitor，acts on TS of Escherichia coli, Lactobacillus casei and human with the IC50 values of 5.0, 3.4 and 119 μM, respectively[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Thymidylate Synthase Research Areas >> Cancer
Target	IC50: 3.4 μM (LcTS)，5.0 μM (EcTS), 119 μM (hTS)[1].
References	[1]. T A Fritz, et al. Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase. Chem Biol. 2001 Oct;8(10):981-95.

RIDADR	NONH for all modes of transport
WGK Germany	3