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29741-09-1

29741-09-1 structure
29741-09-1 structure
  • Name: Apigenin-7-glucuronide
  • Chemical Name: Apigenin 7-glucuronide
  • CAS Number: 29741-09-1
  • Molecular Formula: C21H18O11
  • Molecular Weight: 446.361
  • Catalog: Biochemical Chinese herbal medicine ingredients
  • Create Date: 2018-10-04 17:51:25
  • Modify Date: 2024-01-03 17:07:51
  • Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.
Name Apigenin 7-glucuronide
Synonyms Apigenin 7-O-glucuronide
5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl β-D-glucopyranosiduronic acid
(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[5-hydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxyoxane-2-carboxylic acid
4H-1-Benzopyran-4-one, 7-(β-D-glucopyranuronosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-
Description Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.
Related Catalog
Target

MMP-3:12.87 μM (IC50)

MMP-8:22.39 μM (IC50)

MMP-9:17.52 μM (IC50)

MMP13:0.27 μM (IC50)
In Vitro Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively [1]. Scutellarin A also inhibits the migrated capacity of ACHN and 786-O cells in a dose-dependent manner. It is also revealed that after treatment with Scutellarin A (30, 60, and 90 μM) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkably enhanced dose-dependently when compared to the control groups[2].
References

[1]. Crascì L, et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83(11):901-911.

[2]. Deng W, et al. Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN. Biomed Pharmacother. 2018 Nov;107:1505-1513.
Density 1.7±0.1 g/cm3
Boiling Point 841.8±65.0 °C at 760 mmHg
Melting Point >300℃
Molecular Formula C21H18O11
Molecular Weight 446.361
Flash Point 299.0±27.8 °C
Exact Mass 446.084900
PSA 187.12000
LogP -0.55
Vapour Pressure 0.0±3.3 mmHg at 25°C
Index of Refraction 1.740
Storage condition ?20°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xn
Risk Phrases 22
RIDADR NONH for all modes of transport
Precursor  2

DownStream  2


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