Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: clofibride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

26717-47-5

26717-47-5 structure

Name: clofibride
Chemical Name: [4-(dimethylamino)-4-oxobutyl] 2-(4-chlorophenoxy)-2-methylpropanoate
CAS Number: 26717-47-5
Molecular Formula: C₁₆H₂₂ClNO₄
Molecular Weight: 327.80300
Catalog: Research Areas Metabolic Disease
Create Date: 2018-06-20 16:54:28
Modify Date: 2024-01-11 12:11:45
Clofibride is an orally active hypolipaemic agent of pchlorophenoxyisobutyric type. Clofibride has weak toxicity and marked hypocholesterolaemic and hypotriglyceridaemic activity. Clofibride is converted into 4-chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB) in vivo[1].

Name	[4-(dimethylamino)-4-oxobutyl] 2-(4-chlorophenoxy)-2-methylpropanoate
Synonyms	Butyramide,N-dimethyl-4-(p-chlorophenoxyisobutyrate) Clofibride Clofibrida [INN-Spanish] N-Dimethyl-4-(p-chlorophenoxyisobutyrate)butyramide MG 46 EINECS 247-912-7 Lipenan 3-dimethylcarbamoylpropyl 2-(4-chlorophenoxy)-2-methylpropionate Clofibridum [INN-Latin]

Description	Clofibride is an orally active hypolipaemic agent of pchlorophenoxyisobutyric type. Clofibride has weak toxicity and marked hypocholesterolaemic and hypotriglyceridaemic activity. Clofibride is converted into 4-chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB) in vivo[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vivo	Clofibride (oral, 400; 500 and 1000 mg/kg; single) can rapidly and massively resorb and hydrolys into 4chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB) [1]. Animal Model: Male CD rats, male and female beagles, olive baboon monkeys[1] Dosage: 400, 1000 mg/kg (rats); 500 mg/kg (dogs and monkeys) Administration: oral, single Result: HMB is rapidly metabolized and the half-life of CPIB, the main active metabolite, in the serum is about 12 h in the rat, 43 +9 h in the dog and 6t 1 h in the baboon.

Density	1.163g/cm3
Boiling Point	448.7ºC at 760mmHg
Molecular Formula	C₁₆H₂₂ClNO₄
Molecular Weight	327.80300
Flash Point	225.2ºC
Exact Mass	327.12400
PSA	55.84000
LogP	2.90900
Vapour Pressure	3.04E-08mmHg at 25°C
Index of Refraction	1.515

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UE9458000

CHEMICAL NAME :: Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ester with 4-hydroxy-N,N-dimethylbutyramide

CAS REGISTRY NUMBER :: 26717-47-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H22-Cl-N-O4

MOLECULAR WEIGHT :: 327.84

WISWESSER LINE NOTATION :: GR DOX1&1&VO3VN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2485 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1175 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1080 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 14 gm/kg

SEX/DURATION :: male 7 day(s) pre-mating female 7 day(s) pre-mating female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth

REFERENCE :: JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972

HS Code	2924299090

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

56-41-7	108-65-6
56-35-9	64-17-5
67-56-1	108-88-3
141-78-6	1310-73-2
13463-67-7	1333-86-4