Name | (6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine |
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Synonyms |
Dexpramipexole
(6R)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole (R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (6R)-4,5,6,7-tetrahydro-N6-propylbenzothiazole-2,6-diamine (R)-Pramipexole Dihydrochloride Pramipexole [USAN:INN] (R)-(+)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole (R)-Pramipexole (R)-(+)-pramipexole |
Description | Dexpramipexole(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value:Target: Dopamine ReceptorDexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity. |
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Related Catalog | |
References |
Density | 1.17±0.1 g/cm3 |
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Melting Point | 270-272ºC |
Molecular Formula | C10H17N3S |
Molecular Weight | 211.331 |
PSA | 83.52000 |
LogP | 4.38490 |
Water Solubility | Slightly soluble (1.1 g/L) (25 ºC) |
Hazard Codes | Xi |
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HS Code | 2934999090 |
~% 104632-28-2 |
Literature: WO2013/96816 A1, ; Paragraph 000145-000146 ; |
~% 104632-28-2 |
Literature: Journal of Medicinal Chemistry, , vol. 30, # 3 p. 494 - 498 |
~% 104632-28-2 |
Literature: WO2010/22140 A1, ; Page/Page column 100-101 ; |
~% 104632-28-2 |
Literature: Journal of Medicinal Chemistry, , vol. 30, # 3 p. 494 - 498 |
~% 104632-28-2 |
Literature: Journal of Medicinal Chemistry, , vol. 30, # 3 p. 494 - 498 |
~0% 104632-28-2 |
Literature: GENERICS [UK] LIMITED Patent: WO2006/3471 A2, 2006 ; Location in patent: Page/Page column 9-11 ; |
Precursor 5 | |
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DownStream 0 |
HS Code | 2934999090 |
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Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |