65886-71-7

65886-71-7 structure
65886-71-7 structure
  • Name: 1b-D-Arabinofuranosyl-5-azacytosine
  • Chemical Name: 1-.β.-D-Arabinofuranosyl-5-azacytosine
  • CAS Number: 65886-71-7
  • Molecular Formula: C8H12N4O5
  • Molecular Weight: 244.205
  • Create Date: 2018-09-22 18:11:19
  • Modify Date: 2024-01-13 18:47:40

Name 1-.β.-D-Arabinofuranosyl-5-azacytosine
Synonyms 4-Amino-1-(β-D-arabinofuranosyl)-1,3,5-triazin-2(1H)-one
1b-D-Arabinofuranosyl-5-azacytosine
4-Amino-1b-D-arabinofuranosyl-s-triazin-2(1H)-one
Fazarabine
5-azacytosine arabinoside
ara-AC
1-β-D-Arabinofuranosyl-5-azacytosine
4-Amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
1,3,5-Triazin-2(1H)-one, 4-amino-1-β-D-arabinofuranosyl-
5-azaaracytidine
Density 2.1±0.1 g/cm3
Boiling Point 534.5±60.0 °C at 760 mmHg
Melting Point 228-230ºC (decomposes)
Molecular Formula C8H12N4O5
Molecular Weight 244.205
Flash Point 277.0±32.9 °C
Exact Mass 244.080765
PSA 143.72000
LogP -1.99
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.823

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XZ2854400
CHEMICAL NAME :
s-Triazin-2(1H)-one, 4-amino-1-beta-D-arabinofuranosyl-
CAS REGISTRY NUMBER :
65886-71-7
LAST UPDATED :
199206
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C8-H12-N4-O5
MOLECULAR WEIGHT :
244.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
1557 ug/kg/72H-C
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Blood - agranulocytosis

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
2 umol/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,297,1983