645-43-2

645-43-2 structure

Name: Guanethidine sulfate
Chemical Name: guanethidine monosulfate
CAS Number: 645-43-2
Molecular Formula: C₁₀H₂₄N₄O₄S
Molecular Weight: 296.387
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-07-07 19:29:29
Modify Date: 2024-01-01 18:33:45
Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.IC50 value:Target: Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine.It may also inhibit the release of granules by decreasing norepinephrine.

Name	guanethidine monosulfate
Synonyms	1-[2-(Azocan-1-yl)ethyl]guanidine sulfate (1:1) EINECS 211-442-0 Iporal Guanethidine bisulfate 1-[2-(1-Azocanyl)ethyl]guanidine sulfate Guanidine, N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-, sulfate (1:1) 2-[2-(azocan-1-yl)ethyl]guanidine,sulfuric acid Sanotensin MFCD00035403 1-[2-(1-Azocanyl)ethyl]guanidine sulfate (1:1) 1-[2-(Azocan-1-yl)ethyl]guanidine sulfate Guanethidine Sulfate Ismelin sulfate UNII-5UBY8Y002G Guanetidin sulfate Guanethidine monosulfate 1-[2-(Azocan-1-yl)ethyl]guanidinsulfat N-(2-Guanidino ethyl)heptamethylenimine sulfate 1-(2-azocan-1-ylethyl)guanidine sulfate Ismelin guanethidine sulphate

Description	Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.IC50 value:Target: Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine.It may also inhibit the release of granules by decreasing norepinephrine.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Fabiani ME, et al. Inhibition of sympathetic noradrenergic transmission by guanabenz and guanethidine in rat isolated mesenteric artery: involvement of neuronal potassium channels. Pharmacol Res. 1996 Mar;33(3):171-80. [2]. Joyce PI, et al. The effect of guanethidine and local anesthetics on the electrically stimulated mouse vas deferens. Anesth Analg. 2002 Nov;95(5):1339-43.

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 4,592,1967 ** ACUTE TOXICITY DATA **

REFERENCE :: ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 321,57,1988

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S25-S36
RIDADR	NONH for all modes of transport
RTECS	MF3150000
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%