DC Chemicals Limited
China
Product Name: TIC10 isomer
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Imidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one,2,6,7,8,9,10-hexahydro-10-[(2-methylphenyl)methyl]-7-(phenylmethyl)-
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Purity: 98.0%
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41276-02-2

41276-02-2 structure

41276-02-2 structure

Name: TIC10 Analogue
Chemical Name: tic 10
CAS Number: 41276-02-2
Molecular Formula: C₂₄H₂₆N₄O
Molecular Weight: 386.489
Catalog: Biochemical Inhibitor PI3K/Akt/mTOR inhibitor (PI3K/Akt/mTOR) Akt inhibitor
Create Date: 2016-03-20 23:28:17
Modify Date: 2024-01-05 01:20:16
TIC10 isomer is the isomer of TIC10. TIC10 isomer does not possess the reported biological activity of inducing TRIAL expression.

Name	tic 10
Synonyms	Imidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one, 2,6,7,8,9,10-hexahydro-10-[(2-methylphenyl)methyl]-7-(phenylmethyl)- Potent Akt/ERK inhibitor 7-benzyl-10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one 7-Benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one TIC10 - Isomer TIC10 isomer

Description	TIC10 isomer is the isomer of TIC10. TIC10 isomer does not possess the reported biological activity of inducing TRIAL expression.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
In Vitro	TRAIL (TNF related apoptosis inducing ligand) is a cytokine that kills cancer cells but shows no toxicity against normal cells. Active pharmaceutical ingredient TIC-10 (TRAIL inducing compound 10) (Compound 3a), is an anticancer drug first reported in a 1973 patent. The structure of TIC10 3a had been mis-assigned as TIC10 isomer (Compound 3b) in the initial patent. Subsequent synthesis of the originally reported structure by an alternate route shows TIC10 isomer (Compound 3b) does not possess the reported biological activity of inducing TRIAL expression[1].
References	[1]. Xin D, et al. Development of a 13C NMR Chemical Shift Prediction Procedure Using B3LYP/cc-pVDZ andEmpirically Derived Systematic Error Correction Terms: A Computational Small MoleculeStructure Elucidation Method. J Org Chem. 2017 May 19;82(10):5135-5145.

Density	1.2±0.1 g/cm3
Boiling Point	559.7±60.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₆N₄O
Molecular Weight	386.489
Flash Point	292.3±32.9 °C
Exact Mass	386.210663
PSA	42.53000
LogP	3.19
Appearance	white to beige
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.672
Storage condition	2-8°C
Water Solubility	DMSO: soluble2mg/mL, clear (warmed)

RIDADR	NONH for all modes of transport